The developmental-genetics of canalization.
The developmental-genetics of canalization.
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DOI：
10.1016/j.semcdb.2018.05.019
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发表时间：
2019-04
影响因子：
7.3
通讯作者：
Marcucio RS
中科院分区：
文献类型：
--
作者：
Hallgrimsson B;Green RM;Katz DC;Fish JL;Bernier FP;Roseman CC;Young NM;Cheverud JM;Marcucio RS
运河化，或者说对遗传或环境扰动的鲁棒性，是复杂生物体的基础。虽然有强有力的证据表明运河化是一种随基因型而变化的进化特性，但人们对产生这种现象的发育和遗传机制知之甚少。对于进化生物学来说，了解管道化是如何产生的非常重要，因为通过调节因遗传差异而产生的表型变异，管道化是进化性的决定因素。对于人类疾病遗传学和农业中重要的经济性状来说，这个问题很重要，因为运河化是导致遗传性缺失的潜在重要原因，从而混淆了表型的基因组预测。我们回顾了关于运河化的发育遗传基础的主要思路。这些分为两组。一种提出了特定的进化分子机制，而另一种则将稳健性或渠道化作为发展的更普遍特征。这些对运河化的解释并不相互排斥，而且在几个方面有重叠。对管道化的一般解释更有可能涉及发育的新兴特征，而不是具体的分子机制。由于遗传学和发育生物学之间观点的差异，理清这些解释也变得复杂。从机械层面理解渠道化将取决于整合定量遗传学和发育生物学的概念和方法论。
Canalization, or robustness to genetic or environmental perturbations, is fundamental to complex organisms. While there is strong evidence for canalization as an evolved property that varies among genotypes, the developmental and genetic mechanisms that produce this phenomenon are very poorly understood. For evolutionary biology, understanding how canalization arises is important because, by modulating the phenotypic variation that arises in response to genetic differences, canalization is a determinant of evolvability. For genetics of disease in humans and for economically important traits in agriculture, this question is important because canalization is a potentially significant cause of missing heritability that confounds genomic prediction of phenotypes. We review the major lines of thought on the developmental-genetic basis for canalization. These fall into two groups. One proposes specific evolved molecular mechanisms while the other deals with robustness or canalization as a more general feature of development. These explanations for canalization are not mutually exclusive and they overlap in several ways. General explanations for canalization are more likely to involve emergent features of development than specific molecular mechanisms. Disentangling these explanations is also complicated by differences in perspectives between genetics and developmental biology. Understanding canalization at a mechanistic level will depend on conceptual and methodological approaches that integrate quantitative genetics and developmental biology.
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影响因子：
3.3
作者：
Debat, Vincent;Milton, Claire C.;Hoffmann, Ary A.
通讯作者：
Hoffmann, Ary A.
影响因子：
3.3
作者：
Debat, Vincent;Debelle, Allan;Dworkin, Ian
通讯作者：
Dworkin, Ian
影响因子：
1.5
作者：
CLARKE, GM
通讯作者：
CLARKE, GM
DOI：
10.1098/rspb.2000.1011
发表时间：
2000-02-22
影响因子：
4.7
作者：
Badyaev, AV;Foresman, KR
通讯作者：
Foresman, KR
影响因子：
3.1
作者：
Auffray, JC;Fontanillas, P;Britton-Davidian, J
通讯作者：
Britton-Davidian, J