Ocular Ischemic Syndrome and Its Related Experimental Models.
Ocular Ischemic Syndrome and Its Related Experimental Models.
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DOI：
10.3390/ijms23095249
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发表时间：
2022-05-08
影响因子：
5.6
通讯作者：
中科院分区：
文献类型：
--
作者：
眼缺血综合征（OIS）是由颈动脉狭窄或闭塞引起的严重眼部疾病之一。由于眼动脉起源于颈动脉的分支，颈动脉狭窄或闭塞可引起慢性眼灌注不足，最终导致OIS的发生。到目前为止，OIS的病理生理学仍然没有清楚地阐明。为了更好地探索OIS的病理生理学，已经在大鼠和小鼠中开发了几种实验模型。双侧或单侧进行颈总动脉或颈内动脉的手术闭塞或狭窄用于模型开发。在这方面，即使可以观察到眼部灌注不足的类似结果，但眼部的最终缺血结局也因手术程序而异。在目前的审查中，我们提供了一个概述的病理生理OIS从各种实验模型，以及一些临床病例。此外，我们涵盖了OIS的当前治疗现状，沿着有前途的临床前治疗与最新进展。我们的综述将使更全面的治疗方法，以防止发展和/或进展的OIS。
Ocular ischemic syndrome (OIS) is one of the severe ocular disorders occurring from stenosis or occlusion of the carotid arteries. As the ophthalmic artery is derived from the branch of the carotid artery, stenosis or occlusion of the carotid arteries could induce chronic ocular hypoperfusion, finally leading to the development of OIS. To date, the pathophysiology of OIS is still not clearly unraveled. To better explore the pathophysiology of OIS, several experimental models have been developed in rats and mice. Surgical occlusion or stenosis of common carotid arteries or internal carotid arteries was conducted bilaterally or unilaterally for model development. In this regard, final ischemic outcomes in the eye varied depending on the surgical procedure, even though similar findings on ocular hypoperfusion could be observed. In the current review, we provide an overview of the pathophysiology of OIS from various experimental models, as well as several clinical cases. Moreover, we cover the status of current therapies for OIS along with promising preclinical treatments with recent advances. Our review will enable more comprehensive therapeutic approaches to prevent the development and/or progression of OIS.
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作者：
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通讯作者：
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