Circular RNA hsa_circ_009755 downregulation correlates with clinicopathology in oral squamous cell carcinoma
Circular RNA hsa_circ_009755 downregulation correlates with clinicopathology in oral squamous cell carcinoma
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环状RNA hsa_circ_009755下调与口腔鳞状细胞癌的临床病理学相关
DOI：
10.2147/ott.s196618
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发表时间：
2019-05
影响因子：
4
通讯作者：
杨宏宇
中科院分区：
文献类型：
--
作者：
王子弘;沈月洪;杨宏宇
背景：口腔鳞状细胞癌（OSCC）是人类最常见的口腔恶性肿瘤。越来越多的研究表明，环状RNA（circRNA）在肿瘤发生和肿瘤进展中起着重要作用。目的：研究口腔鳞状细胞癌（OSCC）及其癌旁正常组织中circRNA的表达差异。同时研究circRNA在口腔鳞癌组织中的表达与临床病理特征的关系。患者与方法：收集27例口腔鳞癌患者的原发性口腔鳞癌组织和癌旁正常组织。通过qRT-PCR分析hsa_circ_009755的表达水平。结果如下：qRT-PCR检测结果显示hsa_circ_009755在口腔鳞癌组织和细胞系中均呈低表达，hsa_circ_009755的低表达与口腔鳞癌患者的临床病理特征密切相关。此外，受试者工作特征曲线下面积为0.782，这表明诊断价值的敏感性和特异性。结论：hsa_circ_009755可作为口腔鳞状细胞癌诊断的潜在生物标志物。
Background: Oral squamous cell carcinoma (OSCC) is the most frequent oral malignancy in humans. Increasing numbers of studies suggest that circular RNAs (circRNAs) play a major role in tumorigenesis and tumor progression. Purpose: We aimed to identify differently expressed circRNA in OSCC and adjacent normal tissue. As well as to study the correlation of circRNA expression with clinicopathological feature in patients with OSCC. Patients and methods: Primary OSCC tissues and adjacent normal tissues from twenty-seven OSCC patients were collected. The expression level of hsa_circ_009755 were analyzed by qRT-PCR. Results: The measurement results from qRT-PCR revealed that hsa_circ_009755 expression was low in OSCC tissue samples and cell lines, and the low expression of hsa_circ_009755 was closely related to a clinicopathological feature in patients with OSCC. Moreover, the area under the receiver operating characteristic curve was 0.782, which indicates the sensitivity and specificity of the diagnostic value. Conclusion: Our data indicates that hsa_circ_009755 could serve as a potential biomarker for OSCC diagnosis.
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环状RNA has_circ_0067934在食管鳞状细胞癌中上调并促进增殖
影响因子：
4.6
作者：
Xia W;Qiu M;Chen R;Wang S;Leng X;Wang J;Xu Y;Hu J;Dong G;Xu PL;Yin R
通讯作者：
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影响因子：
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作者：
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circRNA生物合成的调控
影响因子：
4.1
作者：
Chen, Ling-Ling;Yang, Li
通讯作者：
Yang, Li
DOI：
10.1073/pnas.1117815109
发表时间：
2012-03-06
影响因子：
11.1
作者：
Wu, Qingfa;Wang, Ying;Ding, Shou-Wei
通讯作者：
Ding, Shou-Wei