Exercise therapy and recovery after SCI: evidence that shows early intervention improves recovery of function.
Exercise therapy and recovery after SCI: evidence that shows early intervention improves recovery of function.
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SCI后的运动疗法和恢复：显示早期干预的证据改善了功能的恢复。
DOI：
10.1038/sc.2010.167
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发表时间：
2011-05
期刊：
影响因子：
2.2
通讯作者：
Hook, M. A.
中科院分区：
文献类型：
--
作者：
Brown, A. K.;Woller, S. A.;Moreno, G.;Grau, J. W.;Hook, M. A.
这是一项实验性研究。运动训练是目前促进不完全性脊髓损伤（SCI）后功能恢复的最有效策略之一。然而，关于治疗开始的时间以获得最大的恢复益处仍然存在争议。为了解决这个问题，本研究比较了急性期和继发期SCI患者运动的效果。德克萨斯A&M大学，学院站，德克萨斯州，美国。大鼠接受中度脊髓挫伤，并在1天（D1-EX）或8天（D8-EX）后开始运动计划。分别放入透明健身球中，每天60 min，连续14 d。对照组大鼠被放置在不动的运动球中。损伤后28天评估运动和感觉恢复情况。与对照组和D8-EX组相比，D1-EX组大鼠的运动功能（BBB评分）恢复明显更好。此外，分析显示，与对照组和D1-EX大鼠相比，D8-EX组大鼠的触觉反应阈值显著降低，并且运动不能逆转异常性疼痛的症状。与D1-EX组相比，D8-EX组的大鼠在损伤中心尾侧的整个脊柱节段上也具有显著更大的损伤面积。这些结果表明，在SCI急性期实施运动方案可以最大限度地提高功能恢复的潜力。
This was designed as an experimental study. Locomotor training is one of the most effective strategies currently available for facilitating recovery of function after an incomplete spinal cord injury (SCI). However, there is still controversy regarding the timing of treatment initiation for maximal recovery benefits. To address this issue, the present study compares the effects of exercise initiated in the acute and secondary phase of SCI. Texas A&M University, College Station, TX, USA. Rats received a moderate spinal contusion injury and began an exercise program 1 (D1-EX) or 8 days (D8-EX) later. They were individually placed into transparent exercise balls for 60 min per day, for 14 consecutive days. Control rats were placed in exercise balls that were rendered immobile. Motor and sensory recovery was assessed for 28 days after injury. The D1-EX rats recovered significantly more locomotor function (BBB scale) than controls and D8-EX rats. Moreover, analyses revealed that rats in the D8-EX group had significantly lower tactile reactivity thresholds compared with control and D1-EX rats, and symptoms of allodynia were not reversed by exercise. Rats in the D8-EX group also had significantly larger areas of damage across spinal sections caudal to the injury center compared with the D1-EX group. These results indicate that implementing an exercise regimen in the acute phase of SCI maximizes the potential for recovery of function.
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影响因子：
14.5
作者：
Hutchinson, KJ;Gómez-Pinilla, F;Basso, DM
通讯作者：
Basso, DM
影响因子：
2.5
作者：
Norrie, BA;Nevett-Duchcherer, JM;Gorassini, MA
通讯作者：
Gorassini, MA
影响因子：
3.4
作者：
Engesser-Cesar, Christie;Ichiyama, Ronaldo M.;Anderson, Aileen J.
通讯作者：
Anderson, Aileen J.
影响因子：
4.2
作者：
Engesser-Cesar, C;Anderson, AJ;Cotman, CW
通讯作者：
Cotman, CW
影响因子：
4.2
作者：
Berrocal, Yerko;Pearse, Damien D.;Eaton, Mary J.
通讯作者：
Eaton, Mary J.