Prognostic role of Glasgow prognostic score in patients with colorectal cancer: evidence from population studies.
Prognostic role of Glasgow prognostic score in patients with colorectal cancer: evidence from population studies.
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格拉斯哥预后评分对结直肠癌患者的预后作用：来自人群研究的证据
DOI：
10.1038/s41598-017-06577-2
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发表时间：
2017-07-21
影响因子：
4.6
通讯作者：
Wang L
中科院分区：
文献类型：
--
作者：
Liu Y;He X;Pan J;Chen S;Wang L
据报道，格拉斯哥预后评分（GPS）是各种癌症预后的指标。然而，GPS与结直肠癌（CRC）之间的关系仍不清楚。全面检索Pubmed、Embase、科克伦图书馆、Web of Science、ChinaInfo和中国知网，筛选出符合条件的研究，提取总生存期（OS）和癌症特异性生存期（CSS）风险。采用随机效应模型计算联合收割机的风险比（HR）和95%置信区间（CI）。共纳入25篇文献，共5660例受试者。合并结果显示，GPS升高与OS（HR = 2.83，95%CI：2.00- 4.00，P < 0.01）和CSS（HR = 1.94，95%CI：1.51- 2.49，P < 0.01）差相关。这种相关性在原发性可手术患者和晚期不可手术患者中均得到证实。GPS升高与肿瘤淋巴结转移（TNM）分期（OR = 1.44，95%CI：1.010-2.065，P < 0.05）和血清癌胚抗原（CEA）升高（OR = 2.252，95%CI：1.508- 3.362，P < 0.01）密切相关。亚组分析显示，根据样本量、研究地区和GPS水平的截断值等因素，高GPS与不良生存结局显著相关。这些结果表明，GPS可以作为一个可靠的预测指标，CRC患者。
Glasgow prognostic score (GPS) has been reported to be an indicator of prognosis for various cancers. However, the relationship between GPS and colorectal cancers (CRC) remains unclear. A comprehensive search of Pubmed, Embase, Cochrane library, Web of Science, ChinaInfo and Chinese National Knowledge Infrastructure was performed to identify eligible studies, from which the risk of overall survival (OS) and cancer-specific survival (CSS) were extracted. A random-effect model was adopted to combine hazard ratio (HR) and 95% confidence interval (CI). 25 articles with a total of 5660 participants were included. The pooled results indicated that elevated GPS was associated with poor OS (HR = 2.83, 95%CI: 2.00–4.00,P< 0.01) and CSS (HR = 1.94, 95%CI: 1.51–2.49,P< 0.01). This correlation was confirmed both in primary operable and advanced inoperable patients. Increased GPS was also closely related to advanced tumour-node-metastasis (TNM) stage (odds ratio [OR] = 1.44, 95% CI: 1.010–2.065, P < 0.05) and elevated level of serum carcinoembryonic antigen (OR = 2.252, 95% CI: 1.508–3.362,P< 0.01). Subgroup analysis revealed a significant association between high GPS and poor survival outcome according to the factors of sample size, study of region and cut-off value of GPS level. These findings suggest that GPS may serve as a reliable predictive index for patients with CRC.
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影响因子：
1.6
作者：
Li MX;Bi XY;Li ZY;Huang Z;Han Y;Zhou JG;Zhao JJ;Zhang YF;Zhao H;Cai JQ
通讯作者：
Cai JQ
影响因子：
9
作者：
Ishizuka, Mitsuru;Nagata, Hitoshi;Kubota, Keiichi
通讯作者：
Kubota, Keiichi
影响因子：
3
作者：
Ishizuka, Mitsuru;Kubota, Keiichi;Sawada, Tokihiko
通讯作者：
Sawada, Tokihiko
影响因子：
3
作者：
Kishiki, Tomokazu;Masaki, Tadahiko;Sugiyama, Masanori
通讯作者：
Sugiyama, Masanori
影响因子：
8.8
作者：
Jiang, X.;Hiki, N.;Nunobe, S.;Kumagai, K.;Kubota, T.;Aikou, S.;Sano, T.;Yamaguchi, T.
通讯作者：
Yamaguchi, T.