Recombination in hepatitis C virus: identification of four novel naturally occurring inter-subtype recombinants.
Recombination in hepatitis C virus: identification of four novel naturally occurring inter-subtype recombinants.
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丙型肝炎病毒重组：四种新型天然亚型间重组体的鉴定
DOI：
10.1371/journal.pone.0041997
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发表时间：
2012
期刊：
影响因子：
3.7
通讯作者：
Higgins DG
中科院分区：
文献类型：
--
作者：
Shi W;Freitas IT;Zhu C;Zheng W;Hall WW;Higgins DG
丙型肝炎病毒（HCV）重组被认为是罕见的。在这项研究中，我们对1278个全长HCV基因组序列进行了系统发育分析，以确定潜在的重组事件。鉴定出9个基因型间重组，均为先前报道过的。这证实了基因型间HCV重组的罕见性。分析还发现了5个亚型间重组，其中4个为首次记录（EU246930、EU246931、EU246932和EU246937）。具体而言，后者代表了四种不同的新型重组类型（6a/ 60、6e/ 60、6e/6h和6n/ 60），并且RDP中嵌入了7种独立的方法。这四种新型HCV重组病毒的断点位于NS5B编码区，与之前报道的所有断点不同。虽然RDP确定的断点的位置不相同，但它们非常接近。我们的研究表明，虽然重组在HCV中很少见，但这值得进一步研究。
Recombination in Hepatitis C virus (HCV) is considered to be rare. In this study, we performed a phylogenetic analysis of 1278 full-length HCV genome sequences to identify potential recombination events. Nine inter-genotype recombinants were identified, all of which have been previously reported. This confirms the rarity of inter-genotype HCV recombinants. The analysis also identified five inter-subtype recombinants, four of which are documented for the first time (EU246930, EU246931, EU246932, and EU246937). Specifically, the latter represent four different novel recombination types (6a/6o, 6e/6o, 6e/6h, and 6n/6o), and this was well supported by seven independent methods embedded in RDP. The breakpoints of the four novel HCV recombinants are located within the NS5B coding region and were different from all previously reported breakpoints. While the locations of the breakpoints identified by RDP were not identical, they are very close. Our study suggests that while recombination in HCV is rare, this warrants further investigation.
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影响因子：
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