Patterns of antimicrobial drug use in veterinary primary care and specialty practice: A 6-year multi-institution study.
Patterns of antimicrobial drug use in veterinary primary care and specialty practice: A 6-year multi-institution study.
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DOI：
10.1111/jvim.16136
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发表时间：
2021-05
影响因子：
2.6
通讯作者：
Lawhon SD
中科院分区：
文献类型：
--
作者：
Goggs R;Menard JM;Altier C;Cummings KJ;Jacob ME;Lalonde-Paul DF;Papich MG;Norman KN;Fajt VR;Scott HM;Lawhon SD
Combatting antimicrobial resistance requires a One Health approach to antimicrobial stewardship including antimicrobial drug (AMD) use evaluation. Current veterinary AMD prescribing data are limited. To quantify companion animal AMD prescribing in primary care and specialty practice across 3 academic veterinary hospitals with particular focus on third‐generation cephalosporins, fluoroquinolones, and carbapenems. Dogs and cats presented to 3 academic veterinary hospitals from 2012 to 2017. In this retrospective study, AMD prescribing data from 2012 to 2017 were extracted from electronic medical records at each hospital and prescriptions classified by service type: primary care, specialty practice or Emergency/Critical Care (ECC). Hospital‐level AMD prescribing data were summarized by species, service type, AMD class, and drug. Multivariable logistic full‐factorial regression models were used to estimate hospital, year, species, and service‐type effects on AMD prescribing. Estimated marginal means and confidence intervals were plotted over time. The probability of systemic AMD prescribing for any indication ranged between 0.15 and 0.28 and was higher for dogs than cats (P < .05) apart from 2017 at hospital 1. Animals presented to primary care were least likely to receive AMDs (dogs 0.03‐0.15, cats 0.03‐0.18). The most commonly prescribed AMD classes were aminopenicillins/β‐lactamase inhibitors (0.02‐0.15), first‐generation cephalosporins (0.00‐0.09), fluoroquinolones (0.00‐0.04), nitroimidazoles (0.01‐0.06), and tetracyclines (0.00‐0.03). Among the highest priority classes, fluoroquinolones (dogs 0.00‐0.09, cats 0.00‐0.08) and third‐generation cephalosporins (dogs 0.00‐0.04, cats 0.00‐0.05) were most frequently prescribed. Antimicrobial drug prescribing frequencies were comparable to previous studies. Additional stewardship efforts might focus on fluoroquinolones and third‐generation cephalosporins.
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DOI：
10.1016/j.tvjl.2017.03.010
发表时间：
2017-06
期刊：
Veterinary journal (London, England : 1997)
影响因子：
--
作者：
Singleton DA;Sánchez-Vizcaíno F;Dawson S;Jones PH;Noble PJM;Pinchbeck GL;Williams NJ;Radford AD
通讯作者：
Radford AD
影响因子：
2.6
作者：
Hardefeldt, L. Y.;Holloway, S.;Stevenson, M.
通讯作者：
Stevenson, M.
影响因子：
3.3
作者：
Nienhoff, Ulrike;Kadlec, Kristina;Nolte, Ingo
通讯作者：
Nolte, Ingo
影响因子：
3.2
作者：
Singleton, David A.;Noble, P. J. M.;Jones, Philip H.
通讯作者：
Jones, Philip H.
影响因子：
5.2
作者：
Escher, Martina;Vanni, Michele;Scavia, Gaia
通讯作者：
Scavia, Gaia