Dissociated effects of anticipating smoking versus monetary reward in the caudate as a function of smoking abstinence.
Dissociated effects of anticipating smoking versus monetary reward in the caudate as a function of smoking abstinence.
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DOI：
10.1016/j.biopsych.2013.11.013
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发表时间：
2014-11-01
影响因子：
10.6
通讯作者：
Donny, Eric C.
中科院分区：
文献类型：
--
作者：
Sweitzer, Maggie M.;Geier, Charles F.;Joel, Danielle L.;McGurrin, Patrick;Denlinger, Rachel L.;Forbes, Erika E.;Donny, Eric C.
Theories of addiction suggest that chronic smoking may be associated with both hypersensitivity to smoking and related cues and hyposensitivity to alternative reinforcers. However, neural responses to smoking and non-smoking rewards are rarely evaluated within the same paradigm, leaving the extent to which both processes operate simultaneously uncertain. Furthermore, behavioral evidence and theoretical models suggests that dysregulated reward processing may be more pronounced during deprivation from nicotine, but neuroimaging evidence on the effects of deprivation on reward processing is limited. The current study examined the impact of deprivation from smoking on neural processing of both smoking and monetary rewards. Thirty-eight daily smokers participated in two separate fMRI scans, one after smoking without restriction and one following 24 hours of abstinence. A rewarded guessing task was conducted during each scan to evaluate striatal BOLD response during anticipation of both smoking and monetary rewards. A significant reward type X abstinence interaction was observed in the bilateral caudate and medial prefrontal cortex during reward anticipation. BOLD response to anticipation of smoking reward was significantly higher, and anticipation of monetary rewards significantly lower, during abstinence compared with non-abstinence. Furthermore, attenuation of monetary reward-related activation during abstinence was significantly correlated with abstinence-induced increases in craving and withdrawal. These results provide the first direct evidence of dissociated effects of smoking versus monetary rewards as a function of abstinence. The findings suggest an important neural pathway that may underlie the choice to smoke in lieu of alternate reinforcement during a quit attempt.
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