Sirtuins in female meiosis and in reproductive longevity.
Sirtuins in female meiosis and in reproductive longevity.
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DOI：
10.1002/mrd.23437
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发表时间：
2020-12
影响因子：
2.5
通讯作者：
Schindler K
中科院分区：
文献类型：
--
作者：
Vazquez BN;Vaquero A;Schindler K
在减数分裂过程中，遗传物质通过优质配子传递给后代需要精确的同源染色体重组和分离。如果不能完成这些进程，就会对生殖健康造成严重后果，包括不育和后代发育障碍。Sirtuins是NAD+依赖性蛋白去乙酰化酶和adp -核糖基转移酶的一个家族，在基因组维持、代谢和衰老中发挥关键作用。近年来，Sirtuin已成为几种生殖过程的调节因子，针对Sirtuin活性的干预措施在生殖生物学领域引起了极大的兴趣。Sirtuins是保护生殖细胞免受氧化应激的关键，氧化应激是影响卵巢衰老和配子质量的主要决定因素。Sirtuins还通过调节基因抑制、DNA修复和染色体分离等所需的表观遗传程序来保护基因组的完整性。虽然这些功能在许多体细胞组织中都有相对较好的特征，但它们如何影响生殖功能还不是很清楚。本文综述了我们目前对Sirtuins在女性生殖系统中的作用的了解，并讨论了潜在的分子途径。此外，我们强调了Sirtuins作为卵巢抗衰老因子的重要性，并总结了目前临床前的努力，以确定延长女性生殖寿命的治疗方法。
Transmission of genetic material through high quality gametes to progeny requires accurate homologous chromosome recombination and segregation during meiosis. A failure to accomplish these processes can have major consequences in reproductive health, including infertility and development disorders in offspring. Sirtuins, a family of NAD+-dependent protein deacetylases and ADP-ribosyltransferases, play key roles in genome maintenance, metabolism and aging. In recent years, Sirtuins have emerged as regulators of several reproductive processes and interventions aiming to target Sirtuin activity are of great interest in the reproductive biology field. Sirtuins are pivotal to protect germ cells against oxidative stress, a major determinant influencing ovarian aging and the quality of gametes. Sirtuins also safeguard the integrity of the genome through epigenetic programs required for regulating gene repression, DNA repair and chromosome segregation, among others. Although these functions are relatively well characterized in many somatic tissues, how they contribute to reproductive functions is not well understood. This review summarizes our current knowledge on the role of Sirtuins in female reproductive systems and discusses the underlying molecular pathways. In addition, we highlight the importance of Sirtuins as anti-aging factors in the ovary and summarize current preclinical efforts to identify treatments to extend female reproductive longevity.
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DOI：
10.5935/1518-0557.20180003
发表时间：
2018-03-01
期刊：
JBRA assisted reproduction
影响因子：
--
作者：
Adeoye O;Olawumi J;Opeyemi A;Christiania O
通讯作者：
Christiania O
DOI：
10.1186/1477-7827-10-49
发表时间：
2012-06-29
期刊：
Reproductive biology and endocrinology : RB&E
影响因子：
--
作者：
Agarwal A;Aponte-Mellado A;Premkumar BJ;Shaman A;Gupta S
通讯作者：
Gupta S
H3K9ME3依赖性异染色质：细胞命运变化的屏障。
DOI：
10.1016/j.tig.2015.11.001
发表时间：
2016-01
期刊：
Trends in genetics : TIG
影响因子：
--
作者：
Becker JS;Nicetto D;Zaret KS
通讯作者：
Zaret KS
肿瘤抑制因子 SIRT3 脱乙酰并激活锰超氧化物歧化酶清除 ROS
影响因子：
7.7
作者：
Chen, Yaohui;Zhang, Jinye;Lin, Yan;Lei, Qunying;Guan, Kun-Liang;Zhao, Shimin;Xiong, Yue
通讯作者：
Xiong, Yue
影响因子：
4.8
作者：
Gao, Min;Li, Xiaoyan;Gu, Ling
通讯作者：
Gu, Ling