Functional reorganisation and recovery following cortical lesions: A preliminary study in macaque monkeys.
Functional reorganisation and recovery following cortical lesions: A preliminary study in macaque monkeys.
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DOI：
10.1016/j.neuropsychologia.2018.08.024
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发表时间：
2018-10
期刊：
影响因子：
2.6
通讯作者：
Bell AH
中科院分区：
文献类型：
--
作者：
Ainsworth M;Browncross H;Mitchell DJ;Mitchell AS;Passingham RE;Buckley MJ;Duncan J;Bell AH
创伤性脑损伤或中风后的损伤通常会超出最初损伤的范围，并可能导致适应性不良的皮层重组。另一方面，导致功能恢复的有益皮质重组也可能发生。我们使用静息状态FMRI来研究猕猴大脑皮层网络在前额叶皮层损伤后如何随时间变化，以及这种重组如何与认知任务中行为表现的变化相关。在病变前测试和扫描后，两只猴子接受左主沟周围区域的病变，然后进行周期性测试和扫描。之后，这些动物接受了另一个对侧半球的损伤，并进行了额外的测试和扫描。在第一次损伤后，我们观察到行为障碍和功能连接减少，主要是在额额网络。大约8周后，性能和连接模式都得到了改善。在第二次损伤后，我们观察到进一步的行为缺陷和连通性下降，几乎没有恢复。我们讨论了不同的机制，包括替代行为策略和特定前额叶网络的重组可能导致行为的改善。需要进一步的工作来证实这些机制。前额皮质损伤会导致功能连通性下降。与行为障碍相关的功能连接减少。8周后，功能连接模式与行为一起恢复。
Damage following traumatic brain injury or stroke can often extend beyond the boundaries of the initial insult and can lead to maladaptive cortical reorganisation. On the other hand, beneficial cortical reorganisation leading to recovery of function can also occur. We used resting state FMRI to investigate how cortical networks in the macaque brain change across time in response to lesions to the prefrontal cortex, and how this reorganisation correlated with changes in behavioural performance in cognitive tasks. After prelesion testing and scanning, two monkeys received a lesion to regions surrounding the left principal sulcus followed by periodic testing and scanning. Later, the animals received another lesion to the opposite hemisphere and additional testing and scanning. Following the first lesion, we observed both a behavioural impairment and decrease in functional connectivity, predominantly in frontal-frontal networks. Approximately 8 weeks later, performance and connectivity patterns both improved. Following the second lesion, we observed a further behavioural deficit and decrease in connectivity that showed little recovery. We discuss how different mechanisms including alternate behavioural strategies and reorganisation of specific prefrontal networks may have led to improvements in behaviour. Further work will be needed to confirm these mechanisms. Lesions to prefrontal cortex result in decreases in functional connectivity. Decrease in functional connectivity associated with behavioural impairments. After 8 weeks, functional connectivity patterns recover along with behaviour.
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影响因子：
3.5
作者：
Cusack R;Vicente-Grabovetsky A;Mitchell DJ;Wild CJ;Auer T;Linke AC;Peelle JE
通讯作者：
Peelle JE
影响因子：
9.8
作者：
Lebedev MA;Messinger A;Kralik JD;Wise SP
通讯作者：
Wise SP
影响因子：
5.3
作者：
Mitchell, Daniel J.;Bell, Andrew H.;Duncan, John
通讯作者：
Duncan, John
DOI：
10.1523/jneurosci.2318-11.2011
发表时间：
2011-09-07
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Mantini D;Gerits A;Nelissen K;Durand JB;Joly O;Simone L;Sawamura H;Wardak C;Orban GA;Buckner RL;Vanduffel W
通讯作者：
Vanduffel W
影响因子：
2.5
作者：
FUNAHASHI, S;BRUCE, CJ;GOLDMANRAKIC, PS
通讯作者：
GOLDMANRAKIC, PS