Neural activity changes to emotional stimuli in healthy individuals under chronic use of clomipramine.
Neural activity changes to emotional stimuli in healthy individuals under chronic use of clomipramine.
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DOI：
10.1177/0269881109105786
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发表时间：
2010-08
期刊：
影响因子：
--
通讯作者：
Busatto GF
中科院分区：
文献类型：
--
作者：
de Almeida JR;Phillips ML;Cerqueira CT;Zilberman M;Lobo D;Henna E;Tavares H;Amaro E;Gorenstein C;Gentil V;Busatto GF
先前的功能性磁共振成像（fMRI）研究检查了健康个体急性/亚急性服用抗抑郁药后对情绪刺激的神经活动反应。我们现在报告的影响，反复使用抗抑郁药氯丙咪嗪对功能磁共振成像数据采集过程中提出的情绪激发和中性刺激对健康志愿者。12名志愿者在接受低剂量氯丙咪嗪4周后进行了功能磁共振成像评估，并在4周后再次洗脱。使用IAPS中的恐惧、快乐、愤怒和中性图片。数据分析采用统计参数作图法（p<0.05）。配对t检验比较用药和未用药状态之间的每一个条件显示，负效价范式，减少大脑活动时，参与者的杏仁核药物。我们还表明，在正和负效价范式，一致的大脑活动减少前扣带回和扣带回的药物状态。这是第一次报告的调节作用，反复使用抗抑郁药的中央代表性的躯体状态，在健康个体的负面和积极的效价的情绪。此外，我们的研究结果证实了抗抑郁药诱导的颞叶边缘活动的变化，以激发情绪的刺激，在研究中获得的受试者急性治疗这些代理。
Previous functional magnetic resonance imaging(fMRI) studies examined neural activity responses to emotive stimuli in healthy individuals after acute/subacute administration of antidepressants. We now report the effects of repeated use of the antidepressant clomipramine on fMRI data acquired during presentation of emotion-provoking and neutral stimuli on healthy volunteers. Twelve volunteers were evaluated with fMRI after receiving low doses of clomipramine for four weeks, and again after four weeks of washout. Fear-, happiness-, anger-provoking and neutral pictures from the IAPS were used. Data analysis was conducted with statistical parametric mapping(p<0.05). Paired t-test comparisons for each condition between medicated and unmedicated states showed, to negative valence paradigms, decrease brain activity in the amygdala when participants were medicated. We also demonstrated, across both positive and negative valence paradigms, consistent brain activity decreases in the medicated state in the anterior cingulate gyrus and insula. This is the first report of modulatory effects of repeated antidepressant use on the central representation of somatic states in response to emotions of both negative and positive valence in healthy individuals. Also, our results corroborate findings of antidepressant-induced temporolimbic activity changes to emotion-provoking stimuli obtained in studies of subjects treated acutely with such agents.
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影响因子：
7.2
作者：
Aizenstein, Howard J.;Butters, Meryl A.;Wu, Minjie;Mazurkewicz, Laura M.;Stenger, V. Andrew;Gianaros, Peter J.;Becker, James T.;Reynolds, Cbarles F., III;Carter, Cameron S.
通讯作者：
Carter, Cameron S.
影响因子：
5.7
作者：
Kemp, AH;Gray, MA;Nathan, PJ
通讯作者：
Nathan, PJ
影响因子：
5.7
作者：
Maldjian, JA;Laurienti, PJ;Burdette, JH
通讯作者：
Burdette, JH
DOI：
10.1176/appi.neuropsych.19.3.274
发表时间：
2007-06-01
影响因子：
2.9
作者：
Anand, Amit;Li, Yu;Lowe, Mark J.
通讯作者：
Lowe, Mark J.
影响因子：
2.5
作者：
Critchley, HD
通讯作者：
Critchley, HD