Implication of Surface Properties, Bacterial Motility, and Hydrodynamic Conditions on Bacterial Surface Sensing and Their Initial Adhesion.
Implication of Surface Properties, Bacterial Motility, and Hydrodynamic Conditions on Bacterial Surface Sensing and Their Initial Adhesion.
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DOI：
10.3389/fbioe.2021.643722
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发表时间：
2021
影响因子：
5.7
通讯作者：
Hwang G
中科院分区：
文献类型：
--
作者：
Zheng S;Bawazir M;Dhall A;Kim HE;He L;Heo J;Hwang G
生物膜是附着在表面的结构化微生物群落，在医疗和工业环境中对生物污垢的持久性起着重要作用。生物膜中的细菌大多嵌入由细胞外聚合物物质组成的复杂基质中，这些物质提供机械稳定性和对环境逆境的保护。一旦生物膜成熟，杀死细菌或机械去除固体表面的生物膜就变得极其困难。因此，中断细菌表面感知机制和随后细菌与表面的初始结合过程对于有效预防生物膜相关问题至关重要。注意到细菌粘附过程受到许多因素的影响，包括材料的表面特性，本文综述了最近致力于理解表面电荷、表面润湿性、粗糙度、形貌、刚度以及各种特性对细菌粘附的影响的研究工作。本文还重点介绍了在细菌黏附研究中经常被忽视的其他因素，如细菌运动性和流体动力流动的影响。最后，本综述介绍了纳米技术防污系统的最新创新，以设计新的抗菌膜表面概念。
Biofilms are structured microbial communities attached to surfaces, which play a significant role in the persistence of biofoulings in both medical and industrial settings. Bacteria in biofilms are mostly embedded in a complex matrix comprised of extracellular polymeric substances that provide mechanical stability and protection against environmental adversities. Once the biofilm is matured, it becomes extremely difficult to kill bacteria or mechanically remove biofilms from solid surfaces. Therefore, interrupting the bacterial surface sensing mechanism and subsequent initial binding process of bacteria to surfaces is essential to effectively prevent biofilm-associated problems. Noting that the process of bacterial adhesion is influenced by many factors, including material surface properties, this review summarizes recent works dedicated to understanding the influences of surface charge, surface wettability, roughness, topography, stiffness, and combination of properties on bacterial adhesion. This review also highlights other factors that are often neglected in bacterial adhesion studies such as bacterial motility and the effect of hydrodynamic flow. Lastly, the present review features recent innovations in nanotechnology-based antifouling systems to engineer new concepts of antibiofilm surfaces.
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