Association of Maternal Serum 25-hydroxyvitamin D Concentrations in Second Trimester with Delivery Mode in A Chinese Population.
Association of Maternal Serum 25-hydroxyvitamin D Concentrations in Second Trimester with Delivery Mode in A Chinese Population.
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中国人群妊娠中期母体血清 25-羟基维生素 D 浓度与分娩方式的关系
DOI：
10.7150/ijms.20337
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发表时间：
2017
影响因子：
3.6
通讯作者：
Cai M
中科院分区：
文献类型：
--
作者：
Yuan Y;Liu H;Ji C;Guo X;Hu L;Wen J;Cai M
目的：通过研究 1924 名无血缘关系的孕妇，确定中国人群母体血清 25-羟基维生素 D [25(OH)D] 浓度，并探讨其与后续分娩方式的关系。方法：采用酶联免疫吸附试验（ELISA）测定血清25（OH）D浓度。同时收集产妇信息和后续分娩方式。进行逻辑回归分析以评估 25(OH)D 浓度与剖腹产之间的关联。结果：所有受试者的 25(OH)D 血清中位浓度 (IQR) 为 43.4 (35.2-56.9) nmol/L。其中，1225名（63.7%）女性处于25（OH）D缺乏状态（<50.0 nmol/L）。 25(OH)D 浓度因体重指数 (BMI)、胎次和采样季节而异。剖宫产女性年龄较大，BMI和异常妊娠史比例较高，提示高龄、肥胖和异常妊娠史可能是后续剖宫产的危险因素。与50.0至74.9 nmol/L的25(OH)D相比，低25(OH)D浓度(<50.0 nmol/L)的女性与剖腹产没有显着相关性。只有在无异常妊娠史的女性亚组中，较高的25(OH)D(>75.0 nmol/L)浓度才能显着降低剖腹产风险。结论：维生素D缺乏是中国孕妇相当严重的问题。没有证据表明母体血清 25(OH)D 浓度与剖腹产风险增加相关。
Objective: To determine the maternal serum 25-hydroxyvitamin D [25(OH)D] concentrations in a Chinese population and investigate its associations with subsequent delivery mode by studying 1924 unrelated pregnant women. Methods: The serum 25(OH)D concentrations was measured by euzymelinked immunosorbent assay (ELISA). Simultaneously, maternal information and subsequent delivery mode were collected. Logistic regression analysis was performed to assess the associations between 25(OH)D concentrations and caesarean section. Results: The median (IQR) serum concentration of 25(OH)D for the total subjects was 43.4 (35.2-56.9) nmol/L. Among them, 1225 (63.7%) women were in the status of 25(OH)D deficiency (< 50.0 nmol/L). The 25(OH)D concentrations showed significant variation by body mass index (BMI), parity and season of sampling. Women with caesarean section was older, and with higher BMI and rate of abnormal pregnancy history, suggesting advanced age, obesity and abnormal pregnancy history may be the risk factors for the subsequent caesarean section. Compared with 25(OH)D from 50.0 to 74.9 nmol/L, women with low 25(OH)D concentrations (< 50.0 nmol/L) was not significantly associated with caesarean section. Only in the subgroup of the women without abnormal pregnancy history, higher 25(OH)D (> 75.0 nmol/L) concentrations could significantly decrease the risk of caesarean section. Conclusion: Vitamin D deficiency is a quite serious problem in Chinese pregnant women. There is no evidence that the maternal serum 25(OH)D concentrations is associated with increased risk of caesarean section.
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影响因子：
6.8
作者：
Cavalier, Etienne;Delanaye, Pierre;Souberbielle, Jean-Claude
通讯作者：
Souberbielle, Jean-Claude
影响因子：
5.6
作者：
Burris, Heather H.;Rifas-Shiman, Sheryl L.;Camargo, Carlos A., Jr.;Litonjua, Augusto A.;Huh, Susanna Y.;Rich-Edwards, Janet W.;Gillman, Matthew W.
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5.9
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通讯作者：
Halliday J
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作者：
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通讯作者：
Lapillonne, Alexandre
影响因子：
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作者：
Liu, Shiliang;Liston, Robert M.;Kramer, Michael S.
通讯作者：
Kramer, Michael S.