Disrupted social development enhances the motivation for cocaine in rats.
Disrupted social development enhances the motivation for cocaine in rats.
复制标题
DOI：
10.1007/s00213-013-3362-8
复制
发表时间：
2014-04
影响因子：
3.4
通讯作者：
Vanderschuren, Louk J. M. J.
中科院分区：
文献类型：
--
作者：
Baarendse, Petra J. J.;Limpens, Jules H. W.;Vanderschuren, Louk J. M. J.
关键词：
早期的社会经验对行为发展非常重要。特别是，断奶后发育过程中的社交游戏行为被认为有助于获得社交、情感和认知能力。相反，发育过程中的社会侮辱可能导致长期的行为损害，并增加精神障碍的脆弱性，如吸毒成瘾。为了研究在社交游戏行为高度丰富的青少年和青少年早期阶段缺乏社会经验是否会改变大鼠的可卡因自我管理。从出生后第21天到42天，大鼠被社会隔离，然后重新社会化，直到成年。然后，在固定比率和累进比率强化表下评估可卡因自我给药。接下来，在自我给药消失后，确定线索、可卡因和应激诱导的可卡因寻找的恢复。早期的社会隔离导致小剂量(0.083毫克/次输注)可卡因自我注射的获得增强，但用剂量-反应分析评估的对可卡因强化的敏感性在隔离大鼠中没有改变。此外，隔离的大鼠在强化的累进比率时间表下表现出对可卡因的动机增加。寻求可卡因的灭绝和恢复不受早期社会孤立的影响。早期的社会孤立会导致自我吸食可卡因的动机长期增加。因此，断奶后社会发展中的反常现象，如缺乏社交游戏，增加了以后生活中吸毒成瘾的脆弱性。
Early social experiences are of major importance for behavioural development. In particular, social play behaviour during post-weaning development is thought to facilitate the attainment of social, emotional and cognitive capacities. Conversely, social insults during development can cause long-lasting behavioural impairments and increase the vulnerability for psychiatric disorders, such as drug addiction. To investigate whether a lack of social experiences during the juvenile and early adolescent stage, when social play behaviour is highly abundant, alters cocaine self-administration in rats. Rats were socially isolated from postnatal day 21 to 42 followed by re-socialization until adulthood. Cocaine self-administration was then assessed under a fixed ratio and progressive ratio schedule of reinforcement. Next, cue, cocaine and stress-induced reinstatement of cocaine seeking was determined following extinction of self-administration. Early social isolation resulted in an enhanced acquisition of self-administration of a low dose (0.083 mg/infusion) of cocaine, but the sensitivity to cocaine reinforcement, assessed using a dose-response analysis, was not altered in isolated rats. Moreover, isolated rats displayed an increased motivation for cocaine under a progressive ratio schedule of reinforcement. Extinction and reinstatement of cocaine seeking was not affected by early social isolation. Early social isolation causes a long-lasting increase in the motivation to self-administer cocaine. Thus, aberrations in post-weaning social development, such as the absence of social play, enhance the vulnerability for drug addiction later in life.
登录
查看更多内容
影响因子：
10.6
作者：
Diergaarde, Leontien;Pattij, Tommy;De Vries, Taco J.
通讯作者：
De Vries, Taco J.
DOI：
10.1111/j.1530-0277.2011.01437.x
发表时间：
2011-06-01
影响因子：
3.2
作者：
Goudriaan, Anna E.;Grekin, Emily R.;Sher, Kenneth J.
通讯作者：
Sher, Kenneth J.
影响因子：
3.6
作者：
Ding, YJ;Kang, L;Ma, L
通讯作者：
Ma, L
影响因子：
3.3
作者：
Bari, AA;Pierce, RC
通讯作者：
Pierce, RC
影响因子：
19.9
作者：
Cacioppo, John T.;Hawkey, Louise C.
通讯作者：
Hawkey, Louise C.