A systematic review: Candidate gene and environment interaction on alcohol use and misuse among adolescents and young adults.
A systematic review: Candidate gene and environment interaction on alcohol use and misuse among adolescents and young adults.
复制标题
系统评价：有关青少年和年轻人饮酒和滥用的候选基因和环境互动。
DOI：
10.1111/ajad.12755
复制
发表时间：
2018-07-10
期刊：
影响因子：
--
通讯作者：
Park A
中科院分区：
文献类型：
--
作者：
Kim J;Park A
Youth drinking is a pervasive public health concern with serious negative developmental implications. Candidate gene and environment interaction studies (cGxE) show that environmental effects on drinking behaviors may differ by individuals’ genotypes. Yet little is known about whether genetic and environmental effects on drinking behaviors are developmentally specific. This systematic review evaluated 42 cGxE studies of drinking in adolescence and young adulthood. Although there are mixed findings, studies of cGxE effects involving DRD4, 5-HTTLPR, DRD2, and OPRM1genotypes showed relatively consistent patterns. The effects of under-controlled environments (e.g., low levels of parental monitoring) on early and middle adolescent drinking appeared to differ across DRD2 or OPRM1 genotypes. Effects of alcohol-facilitating environments (e.g., heavy drinking peers) on late adolescent and young adult drinking appeared to differ across DRD4 or OPRM1 genotypes. Interactions between 5-HTTLPR genotype with stressful environments (e.g., negative life events) were found throughout adolescence and young adulthood, although there were some inconsistencies regarding the risk-conferring allele. There was limited evidence for other cGxE effects due to the small number of studies. This review suggests that GxE findings may advance our knowledge regarding which developmentally specific conditions result in the expression of candidate genes that influence youth alcohol use and misuse. However, since a significant number of studies had small sample sizes and most studies had small effect sizes, findings need replication across independent studies with large samples.
登录
查看更多内容
DOI：
10.1111/ajad.12478
发表时间：
2017-08
期刊：
The American journal on addictions
影响因子：
--
作者：
Chartier KG;Karriker-Jaffe KJ;Cummings CR;Kendler KS
通讯作者：
Kendler KS
DOI：
10.1007/s11121-017-0749-5
发表时间：
2018-01
期刊：
Prevention science : the official journal of the Society for Prevention Research
影响因子：
--
作者：
Cleveland HH;Griffin AM;Wolf PSA;Wiebe RP;Schlomer GL;Feinberg ME;Greenberg MT;Spoth RL;Redmond C;Vandenbergh DJ
通讯作者：
Vandenbergh DJ
影响因子：
10.6
作者：
Covault, Jonathan;Tennen, Howard;Kranzler, Henry R.
通讯作者：
Kranzler, Henry R.
DOI：
10.15288/jsa.2002.63.305
发表时间：
2002-05-01
期刊：
JOURNAL OF STUDIES ON ALCOHOL
影响因子：
--
作者：
Barnow, S;Schuckit, MA;Freyberger, HJ
通讯作者：
Freyberger, HJ
影响因子：
3.7
作者：
Blomeyer D;Buchmann AF;Lascorz J;Zimmermann US;Esser G;Desrivieres S;Schmidt MH;Banaschewski T;Schumann G;Laucht M
通讯作者：
Laucht M