Plasmodium falciparum coinfection is associated with improved IgE and IgG3 response against hookworm antigens.
Plasmodium falciparum coinfection is associated with improved IgE and IgG3 response against hookworm antigens.
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恶性疟原虫合并感染可改善对钩虫抗原的IgE和IgG3反应。
DOI：
10.1002/hsr2.672
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发表时间：
2022-07
影响因子：
2
通讯作者：
Amoani, Benjamin
中科院分区：
文献类型：
--
作者：
Sakyi, Samuel A.;Wilson, Michael D.;Adu, Bright;Opoku, Stephen;Brewoo, Antwi;Larbi, Amma;Baafour, Emmanuel K.;Tchum, Samuel K.;Saahene, Roland O.;Aniagyei, Wilfred;Sewor, Christian;Courtin, David;Cappello, Michael;Gyan, Ben;Amoani, Benjamin
恶性疟原虫和钩虫感染在西非很普遍，它们会导致儿童缺铁性贫血和蛋白质营养不良。这些寄生虫的免疫反应相互作用，它们之间的相互作用可能对疫苗的开发和效力产生影响。目前根除钩虫的目标在于接种疫苗。我们评估了恶性疟原虫合并感染和阿苯达唑治疗对自然获得性钩虫L3期幼虫抗原抗体谱的影响。在一项纵向研究中，招募了40名仅感染美洲钩虫的个体，63名感染美洲钩虫和恶性疟原虫的参与者，以及36名非地方性对照（NECs）。这项研究是在加纳的金坦波北部大都市进行的。采集粪便和血液样本进行实验室分析。治疗前和治疗后3周分别采集血清样本。疟疾-钩虫（美洲蜱和恶性疟原虫）共感染组的IgE （β = 0.30, 95% CI = [0.12, 0.48], p = 0.023）和IgG3 （β = 0.15, 95% CI = [0.02, 0.52], p = 0.004）水平明显高于仅感染钩虫（美洲蜱）组。美洲美洲鼠组IgG3水平显著高于对照组（β = 0.39, 95% CI = [0.14-0.62], p = 0.002）。同样，美洲疟原虫和恶性疟原虫共同感染的受试者IgE （β = 0.35, 95% CI = [0.70-0.39], p = 0.002）和IgG3 （β = 0.54, 95% CI = [0.22-0.76], p = 0.002）水平显著升高。此外，阿苯达唑治疗可显著降低针对钩虫L3期幼虫的IgE、IgA、IgM和IgG3抗体（p < 0.05）。恶性疟原虫与改善针对钩虫L3期幼虫的IgE和IgG应答相关。单剂量阿苯达唑治疗导致对钩虫感染的自然获得性免疫反应降低。因此，恶性疟原虫感染可能对钩虫疫苗的有效性有促进作用。
Plasmodium falciparum and Hookworm infections are prevalent in West Africa and they cause iron deficiency anemia and protein malnutrition in Children. Immune response of these parasites interact and their interactions could have repercussions on vaccine development and efficacy. The current goal of hookworm eradication lies on vaccination. We evaluated the effect of P. falciparum coinfection and albendazole treatment on naturally acquired antibody profile against hookworm L3 stage larvae antigen. In a longitudinal study, 40 individuals infected with Necator americanus only, 63 participants infected with N. americanus and P. falciparum, and 36 nonendemic controls (NECs) were recruited. The study was done in the Kintampo North Metropolis of Ghana. Stool and blood samples were taken for laboratory analyses. Serum samples were obtained before hookworm treatment and 3 weeks after treatment. The malaria‐hookworm (N. americanus and P. falciparum) coinfected subjects had significantly higher levels of IgE (β = 0.30, 95% CI = [0.12, 0.48], p = 0.023) and IgG3 (β = 0.15, 95% CI = [0.02, 0.52], p = 0.004) compared to those infected with hookworm only (N. americanus). The N. americanus groups had significantly higher levels of IgG3 (β = 0.39, 95% CI = [0.14–0.62], p = 0.002) compared to the control group. Similarly, N. americanus and P. falciparum coinfected participants had significantly higher levels of IgE (β = 0.35, 95% CI = [0.70–0.39], p = 0.002) and IgG3 (β = 0.54, 95% CI = [0.22–0.76], p = 0.002). Moreover, albendazole treatment led to a significant reduction in IgE, IgA, IgM, and IgG3 antibodies against hookworm L3 stage larvae (p < 0.05) P. falciparum is associated with improved IgE and IgG response against hookworm L3 stage larvae. Treatment with single dose of albendazole led to reduction in naturally acquired immune response against hookworm infection. Thus, P. falciparum infection may have a boosting effect on hookworm vaccine effectiveness.
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影响因子：
2.4
作者：
Imai, Natsuko;Rujeni, Nadine;Nausch, Norman;Bourke, Claire D.;Appleby, Laura J.;Cowan, Graeme;Gwisai, Reggis;Midzi, Nicholas;Cavanagh, David;Mduluza, Takafira;Taylor, David;Mutapi, Francisca
通讯作者：
Mutapi, Francisca
影响因子：
11.8
作者：
Diemert, David J.;Bethony, Jeffrey M.;Hotez, Peter J.
通讯作者：
Hotez, Peter J.
DOI：
10.1007/978-1-4939-1489-0_5
发表时间：
2014-01-01
期刊：
HOW HELMINTHS ALTER IMMUNITY TO INFECTION
影响因子：
--
作者：
Layland, Laura E.;Specht, Sabine
通讯作者：
Specht, Sabine
影响因子：
81.5
作者：
Loukas, Alex;Hotez, Peter J.;Bethony, Jeffrey M.
通讯作者：
Bethony, Jeffrey M.
影响因子：
3.1
作者：
de Moira, Angela Pinot;Jones, Frances M.;Dunne, David W.
通讯作者：
Dunne, David W.