Transcranial focused ultrasound-mediated neurochemical and functional connectivity changes in deep cortical regions in humans.
Transcranial focused ultrasound-mediated neurochemical and functional connectivity changes in deep cortical regions in humans.
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DOI：
10.1038/s41467-023-40998-0
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发表时间：
2023-09-01
影响因子：
16.6
通讯作者：
Fouragnan, Elsa F.
中科院分区：
文献类型：
--
作者：
Yaakub, Siti N.;White, Tristan A.;Roberts, Jamie;Martin, Eleanor;Verhagen, Lennart;Stagg, Charlotte J.;Hall, Stephen;Fouragnan, Elsa F.
低强度经颅超声刺激（TUS）是一种新兴的非侵入性局部调节人脑功能的技术。人类TUS神经调节的机制和神经化学底物以及这些与兴奋和抑制的关系仍然知之甚少。在24名健康对照者中，我们分别刺激两个深层皮质区域，并研究了θ-突发TUS（一种可增加皮质脊髓兴奋性的协议）对抑制性神经递质γ-氨基丁酸（GABA）和功能连接的影响。我们发现，θ-突发TUS在人类中选择性地减少GABA水平的后扣带，但不是背侧前扣带皮层。在这两个地区，TUS后功能连接增加。我们的研究结果表明，TUS通过减少GABA能抑制来改变整体兴奋性，并且TUS介导的神经可塑性的变化在刺激后至少持续50分钟。TUS对后扣带和前扣带的影响差异可能表明TUS效应的状态或位置依赖性-这两种机制越来越多地被认为会影响大脑对神经调节的反应。人类经颅超声刺激（TUS）的神经机制尚未完全了解。在这里，作者表明，θ波刺激降低了后扣带皮层中的γ-氨基丁酸（GABA）水平，并增加了前扣带皮层和后扣带皮层的功能连接。
Low-intensity transcranial ultrasound stimulation (TUS) is an emerging non-invasive technique for focally modulating human brain function. The mechanisms and neurochemical substrates underlying TUS neuromodulation in humans and how these relate to excitation and inhibition are still poorly understood. In 24 healthy controls, we separately stimulated two deep cortical regions and investigated the effects of theta-burst TUS, a protocol shown to increase corticospinal excitability, on the inhibitory neurotransmitter gamma-aminobutyric acid (GABA) and functional connectivity. We show that theta-burst TUS in humans selectively reduces GABA levels in the posterior cingulate, but not the dorsal anterior cingulate cortex. Functional connectivity increased following TUS in both regions. Our findings suggest that TUS changes overall excitability by reducing GABAergic inhibition and that changes in TUS-mediated neuroplasticity last at least 50 mins after stimulation. The difference in TUS effects on the posterior and anterior cingulate could suggest state- or location-dependency of the TUS effect—both mechanisms increasingly recognized to influence the brain’s response to neuromodulation. The neural mechanisms underlying transcranial ultrasound stimulation (TUS) in humans are not well understood. Here, the authors show that theta-burst stimulation reduces gamma-aminobutyric acid (GABA) levels in the posterior cingulate cortex, as well as increasing functional connectivity in the anterior and posterior cingulate cortex.
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影响因子：
2.3
作者：
Maddock, Richard J.;Caton, Michael D.;Ragland, J. Daniel
通讯作者：
Ragland, J. Daniel
影响因子：
2.4
作者：
Ai L;Bansal P;Mueller JK;Legon W
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Legon W
影响因子：
4.6
作者：
Lee W;Kim HC;Jung Y;Chung YA;Song IU;Lee JH;Yoo SS
通讯作者：
Yoo SS
影响因子：
4.4
作者：
Edden, Richard A. E.;Puts, Nicolaas A. J.;Harris, Ashley D.;Barker, Peter B.;Evans, C. John
通讯作者：
Evans, C. John
影响因子：
7.7
作者：
Bachtiar V;Near J;Johansen-Berg H;Stagg CJ
通讯作者：
Stagg CJ