Systemic immune system alterations in early stages of Alzheimer's disease.
Systemic immune system alterations in early stages of Alzheimer's disease.
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DOI：
10.1016/j.jneuroim.2013.01.002
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发表时间：
2013-03-15
影响因子：
3.3
通讯作者：
McGrath, Michael S.
中科院分区：
文献类型：
--
作者：
Zhang, Rongzhen;Miller, Robert G.;Madison, Catherine;Jin, Xia;Honrada, Ronald;Harris, Will;Katz, Jonathan;Forshew, Dallas A.;McGrath, Michael S.
关键词：
免疫激活和炎症在阿尔茨海默病（AD）的发病机制中发挥着重要作用。为了测试 AD 患者是否表现出全身炎症表现，我们对 41 名早期 AD 患者和 31 名年龄匹配的老年对照者的血液进行了评估。早期 AD 患者的单核细胞/巨噬细胞 (MO) 激活和 CD8 T 淋巴细胞的细胞标记物增加。单核细胞CCR2（单核细胞趋化蛋白1（MCP-1）的受体）的表达下降；然而，AD 患者血浆 MCP-1 水平显着升高，且与 MO 激活程度相关。这些发现表明 AD 发病机制可能受到全身免疫功能障碍的影响，并为治疗干预提供了潜在的免疫靶点。
Immune activation and inflammation play significant roles in the pathogenesis of Alzheimer’s disease (AD). To test whether AD patients showed systemic manifestations of inflammation, blood from 41 patients with early stages of AD and 31 aged-match elderly controls were evaluated. Cellular markers for monocyte/macrophage (MO) activation and CD8 T lymphocyte were increased in early AD patients. Expression of monocyte CCR2, the receptor for monocyte chemoattractant protein-1 (MCP-1), was decreased; however, plasma MCP-1 levels were significantly increased and were related to degree of MO activation in AD. These findings suggest that AD pathogenesis may be influenced by systemic immunologic dysfunction and provides potential immunologic targets for therapeutic intervention.
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影响因子：
2.4
作者：
GIOMETTO, B;ARGENTIERO, V;TAVOLATO, B
通讯作者：
TAVOLATO, B
影响因子：
2.8
作者：
Kusdra, L;Rempel, H;Pulliam, L
通讯作者：
Pulliam, L
影响因子：
2.6
作者：
Kim SM;Song J;Kim S;Han C;Park MH;Koh Y;Jo SA;Kim YY
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Kim YY
影响因子：
6.4
作者：
Hickey, William F.
通讯作者：
Hickey, William F.
影响因子：
6.1
作者：
Edison, Paul;Archer, Hilary A.;Brooks, David J.
通讯作者：
Brooks, David J.