The Efficacy and Psychoneuroimmunology Mechanism of Camouflage Combined With Psychotherapy in Vitiligo Treatment.
The Efficacy and Psychoneuroimmunology Mechanism of Camouflage Combined With Psychotherapy in Vitiligo Treatment.
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DOI：
10.3389/fmed.2022.818543
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发表时间：
2022
影响因子：
3.9
通讯作者：
Li, Chunying
中科院分区：
文献类型：
--
作者：
Chang, Yuqian;Zhang, Shaolong;Zhang, Weigang;Li, Shuli;Li, Chunying
伪装与心理治疗相结合的疗效和潜在的机制在白癜风管理中知之甚少。本研究旨在研究联合疗效，并进一步探讨心理-神经-内分泌-免疫-皮肤相互作用。在一项前瞻性、非随机和同期对照试验中，患者被分为两组。生活质量（QOL）采用白癜风生活质量指数（VLQI-C）中文版进行评价。采用酶联免疫吸附法检测血清神经肽和细胞因子水平。共纳入149例患者进行最终评价。治疗4周后，干预组生活质量总分及各亚类评分均明显低于对照组。干预组活动期和稳定期患者血清神经肽Y（NPY）和黑色素浓集激素（MCH）水平均显著降低，促肾上腺皮质激素（ACTH）水平升高，而对照组无明显变化。此外，干预组活动期和稳定期患者的干扰素-γ（IFN-γ）、CXC趋化因子配体10（CXCL 10）和白细胞介素-1 β（IL-1β）血清水平均降低，而对照组仅活动期患者降低。伪装和心理治疗的组合提供了一个临床上有意义的改善生活质量和改善的结果，可能通过调节白癜风管理期间的心理神经内分泌免疫皮肤系统。www.clinicaltrials.gov/ct2/show/NCT03540966，标识符：NCT 03540966。
The efficacy of camouflage combined with psychotherapy and the underlying mechanisms are poorly understood in vitiligo management. This study aimed to investigate the joint efficacy and further explore psycho-neuro-endocrine-immune-skin interactions. In a prospective, non-randomized and concurrent controlled trial, patients were divided into two groups. Quality of life (QOL) was evaluated using the Chinese version of the Vitiligo Life Quality Index (VLQI-C). Serum levels of neuropeptides and cytokines were detected by enzyme-linked immunosorbent assay. A total of 149 patients were included for final evaluation. After treatment for 4 weeks, total and subcategory quality of life scores in the intervention group were much lower than in the control group. Serum levels of neuropeptide-Y (NPY) and melanin-concentrating hormone (MCH) significantly decreased, and serum level of adrenocorticotropic hormone (ACTH) increased in both active and stable patients of the intervention group, but not in the control group. In addition, the serum levels of interferon-γ (IFN-γ), CXC chemokine ligand 10 (CXCL10), and interleukin-1β (IL-1β) decreased in both the active and stable patients of the intervention group and only in the active patients of the control group. The combination of camouflage and psychotherapy provided a clinically meaningful improvement in quality of life and ameliorated the outcome by likely modulating the psycho-neuro-endocrine-immuno-skin system during vitiligo management. www.clinicaltrials.gov/ct2/show/NCT03540966, identifier: NCT03540966.
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