Microbial signature profiles of periodontally healthy and diseased patients.
Microbial signature profiles of periodontally healthy and diseased patients.
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DOI：
10.1111/jcpe.12302
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发表时间：
2014-11
影响因子：
6.7
通讯作者：
Colombo AP
中科院分区：
文献类型：
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作者：
Lourenço TG;Heller D;Silva-Boghossian CM;Cotton SL;Paster BJ;Colombo AP
确定区分牙周健康和不同形式牙周疾病的微生物谱。从牙周健康（27）、牙龈炎（11）、慢性牙周炎（35）和侵袭性牙周炎（24）的患者获得龈下生物膜，并使用HOMIM分析>250种/牙周类型的存在。通过Mann-Whitney检查组间微生物差异。进行回归分析以确定疾病的微生物风险指标。在牙周病患者中，推定的和潜在的新牙周病原体比牙周健康者更普遍。牙髓紫单胞菌/紫单胞菌属的检测(OR 9.5 [1.2-73.1]）和坦那氏菌（OR 38.2 [3.2-450.6]），以及缺乏多糖奈瑟菌（OR 0.004 [0-0.15]）和齿垢普雷沃菌（OR 0.014 [0-0.49]，p<0.05）是牙周病的危险指标。存在伴放线聚集杆菌（OR 29.4 [3.4-176.5]）、人心杆菌（OR 14.9 [2.3-98.7]）、消化链球菌科属（OR 35.9 [2.7-483.9]）、解乳假单胞菌（OR 31.3 [2.1-477.2]），不存在Fretibacterium spp.。(OR 0.024 [0.002-0.357]）、naviforme梭杆菌/具核梭杆菌ss vincentii（OR 0.015 [0.001-0.223]）、granulicatella adiacens/Granulicatella elegans（OR 0.013 [0.001-0.233]，p<0.05）与侵袭性牙周炎相关。龈下生物膜具有特定的微生物特征，能够区分牙周健康和疾病的微生物组。这些特征可用于确定疾病风险。
To determine microbial profiles that discriminate periodontal health from different forms of periodontal diseases. Subgingival biofilm was obtained from patients with periodontal health (27), gingivitis (11), chronic periodontitis (35) and aggressive periodontitis (24), and analyzed for the presence of >250 species/phylotypes using HOMIM. Microbial differences among groups were examined by Mann-Whitney. Regression analyses were performed to determine microbial risk indicators of disease. Putative and potential new periodontal pathogens were more prevalent in subjects with periodontal diseases than periodontal health. Detection of Porphyromonas endodontalis/Porphyromonas spp. (OR 9.5 [1.2–73.1]) and Tannerella forsythia (OR 38.2 [3.2–450.6]), and absence of Neisseria polysaccharea (OR 0.004 [0–0.15]) and Prevotella denticola (OR 0.014 [0–0.49], p<0.05) were risk indicators of periodontal disease. Presence of Aggregatibacter actinomycetemcomitans (OR 29.4 [3.4–176.5]), Cardiobacterium hominis (OR 14.9 [2.3–98.7]), Peptostreptococcaceae sp. (OR 35.9 [2.7–483.9]), P. alactolyticus (OR 31.3 [2.1–477.2]), and absence of Fretibacterium spp. (OR 0.024 [0.002–0.357]), Fusobacterium naviforme/Fusobacterium nucleatum ss vincentii (OR 0.015 [0.001–0.223]), Granulicatella adiacens/Granulicatella elegans (OR 0.013 [0.001–0.233], p<0.05) were associated with aggressive periodontitis. There were specific microbial signatures of the subgingival biofilm that were able to distinguish between microbiomes of periodontal health and diseases. Such profiles may be used to establish risk of disease.
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影响因子：
3.7
作者：
Ge X;Rodriguez R;Trinh M;Gunsolley J;Xu P
通讯作者：
Xu P
影响因子：
2.9
作者：
Huang S;Yang F;Zeng X;Chen J;Li R;Wen T;Li C;Wei W;Liu J;Chen L;Davis C;Xu J
通讯作者：
Xu J
影响因子：
3.7
作者：
Gonçalves PF;Klepac-Ceraj V;Huang H;Paster BJ;Aukhil I;Wallet SM;Shaddox LM
通讯作者：
Shaddox LM
影响因子：
9.4
作者：
Kumar, Purnima S.;Leys, Eugene J.;Griffen, Ann L.
通讯作者：
Griffen, Ann L.
DOI：
10.1038/ismej.2010.30
发表时间：
2010-08
期刊：
The ISME journal
影响因子：
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作者：
通讯作者：
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