Stem cells from deciduous tooth repair mandibular defect in swine.
Stem cells from deciduous tooth repair mandibular defect in swine.
复制标题
猪乳牙干细胞修复下颌缺损
DOI：
10.1177/0022034509333804
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发表时间：
2009-03
影响因子：
7.6
通讯作者：
Wang SL
中科院分区：
文献类型：
--
作者：
Zheng Y;Liu Y;Zhang CM;Zhang HY;Li WH;Shi S;Le AD;Wang SL
来自人类脱落乳牙的干细胞已被鉴定为一种新的产后干细胞群，具有多向分化能力，包括体内矿化组织的再生。为了检查利用这些干细胞再生口面部骨缺损的功效，我们从小型猪乳牙中分离出干细胞，并将其移植到猪下颌骨模型中产生的临界尺寸骨缺损中。我们的结果表明，来自小型猪乳牙的干细胞是一种自体且易于获取的干细胞来源，能够在重建术后 6 个月内移植和再生骨骼，以修复临界大小的下颌骨缺损。这项在大型动物模型（特别是猪）中进行的临床前研究，可以测试干细胞/支架结构在口面部骨骼缺陷修复中的作用，并在人体临床试验中快速转化基于干细胞的口面部重建疗法。
Stem cells from human exfoliated deciduous teeth have been identified as a new post-natal stem cell population with multipotential differentiation capabilities, including regeneration of mineralized tissues in vivo. To examine the efficacy of utilizing these stem cells in regenerating orofacial bone defects, we isolated stem cells from miniature pig deciduous teeth and engrafted the critical-size bone defects generated in swine mandible models. Our results indicated that stem cells from miniature pig deciduous teeth, an autologous and easily accessible stem cell source, were able to engraft and regenerate bone to repair critical-size mandibular defects at 6 months post-surgical reconstruction. This pre-clinical study in a large-animal model, specifically swine, allows for testing of a stem cells/scaffold construct in the restoration of orofacial skeletal defects and provides rapid translation of stem-cell-based therapy in orofacial reconstruction in human clinical trials.
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影响因子：
4.1
作者：
Akintoye, Sunday O.;Lam, Thanh;Robey, Pamela G.
通讯作者：
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影响因子：
4
作者：
Gronthos, S;Zannettino, ACW;Simmons, PJ
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DOI：
10.1016/j.ijrobp.2005.04.029
发表时间：
2005-08-01
影响因子：
7
作者：
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通讯作者：
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影响因子：
6.2
作者：
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通讯作者：
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