Investigation of anterior cingulate cortex gamma-aminobutyric acid and glutamate-glutamine levels in obsessive-compulsive disorder using magnetic resonance spectroscopy
Investigation of anterior cingulate cortex gamma-aminobutyric acid and glutamate-glutamine levels in obsessive-compulsive disorder using magnetic resonance spectroscopy
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使用磁共振波谱研究强迫症中前扣带皮层γ-氨基丁酸和谷氨酸-谷氨酰胺水平
DOI：
10.1186/s12888-019-2160-1
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发表时间：
2019-05
期刊：
影响因子：
4.4
通讯作者：
Fuhua Yan
中科院分区：
文献类型：
--
作者：
Yan Li;Chen Cheng Zhang;Kathrin Weidacker;Yingying Zhang;Naying He;Haiyan Jin;Weibo Chen;Valerie Voon;Richard A E Edden;Fuhua Yan
背景强迫症（Obsessive-compulsive disorder，OCD）是一种相对常见的致残性精神疾病，其病理生理机制尚不完全清楚。在这项研究中，我们利用磁共振波谱（MRS）的努力，以提供一个更好的理解脑γ-氨基丁酸（GABA）和谷氨酸在强迫症的病理生理学的作用。我们假设，除了这些神经递质系统的单独影响，GABA和谷氨酸之间的平衡中断可能是特别相关的强迫症。MethodsWe获得的前扣带皮层的GABA和谷氨酸浓度的MRS测量23例成人患者与强迫症和20个性别和年龄匹配的健康社区志愿者。已建立的临床评定量表被用来评估强迫症，焦虑和抑郁症状的严重程度。统计分析涉及评估GABA和谷氨酸的个体测量值以及GABA与谷氨酸测量值的比率中的患者-对照组差异。此外，我们探讨是否存在差异的MRS措施之间的两个亚组的患者形成根据他们的强迫症症状的严重程度。最后，我们评估了人口统计学和临床变量的关系，以MRS measurements.ResultsPatients与强迫症显示了较高的估计GABA水平和较高的GABA谷氨酸比健康参与者，但没有显着的组间差异，观察谷氨酸的措施。MRS的措施并没有不同的亚组，并没有表现出相关性与人口和临床variables.ConclusionsThese结果表明，GABA异常内的前扣带皮层的病理生理学强迫症。结果未能提供证据表明谷氨酸异常单独参与成人强迫症。然而，似乎谷氨酸和GABA神经传递之间的平衡中断可能在强迫症的病理生理学中发挥特别重要的作用。
BackgroundObsessive-compulsive disorder (OCD) is a relatively common and disabling psychiatric disorder whose pathophysiology is incompletely understood. In this study, we utilized magnetic resonance spectroscopy (MRS) in an effort to provide a better understanding of the role of brain gamma-aminobutyric acid (GABA) and glutamate in the pathophysiology of OCD. We hypothesized that beyond the separate effects of these neurotransmitter systems, a disruption in the balance between GABA and glutamate could be particularly relevant to OCD.MethodsWe obtained MRS measures of GABA and glutamate concentrations in the anterior cingulate cortex from 23 adult patients with OCD and 20 sex- and age-matched healthy community volunteers. Established clinical rating scales were used to assess the severities of OCD, anxiety, and depression symptoms. Statistical analysis involved the assessment of patient-control group differences in the individual measures of GABA and glutamate, as well as in the ratio of the GABA to glutamate measures. Additionally, we explored whether differences in the MRS measures existed between two subgroups of patients formed according to the severity of their OCD symptoms. Finally, we assessed the relations of demographic and clinical variables to the MRS measures.ResultsPatients with OCD displayed a higher estimated GABA level and a higher GABA to glutamate ratio than healthy participants, but no significant group differences were observed in the measure of glutamate. The MRS measures did not vary by subgroup and showed no correlations with demographic and clinical variables.ConclusionsThese results indicate that GABA abnormalities within the anterior cingulate cortex contribute to the pathophysiology of OCD. The results fail to provide evidence that glutamate abnormalities alone are involved in adult OCD. Yet, it seems that a disruption in the balance between glutamate and GABA neurotransmission may have a particularly important role to play in OCD pathophysiology.
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影响因子：
5.3
作者：
通讯作者：
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影响因子：
3.8
作者：
Russo AJ;Pietsch SC
通讯作者：
Pietsch SC
影响因子：
4.4
作者：
Puts, Nicolaas A. J.;Barker, Peter B.;Edden, Richard A. E.
通讯作者：
Edden, Richard A. E.
DOI：
10.1097/01.chi.0000132812.44664.2d
发表时间：
2004-09-01
影响因子：
13.3
作者：
Rosenberg, DR;Mirza, Y;Moore, GJ
通讯作者：
Moore, GJ
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期刊：
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