Urinary Concentrations of the Antibacterial Agent Triclocarban in United States Residents: 2013-2014 National Health and Nutrition Examination Survey.
Urinary Concentrations of the Antibacterial Agent Triclocarban in United States Residents: 2013-2014 National Health and Nutrition Examination Survey.
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DOI：
10.1021/acs.est.6b04668
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发表时间：
2016-12-20
影响因子：
11.4
通讯作者：
Calafat AM
中科院分区：
文献类型：
--
作者：
Ye X;Wong LY;Dwivedi P;Zhou X;Jia T;Calafat AM
三氯卡班被广泛用作个人护理产品中的抗菌剂，并且存在人体暴露的可能性。我们在这里介绍了参加2013-2014年国家健康和营养检查调查的≥6岁美国人中三氯卡班暴露的第一次全国代表性评估。在2686份尿样中，三氯卡班浓度> 0.1 μg/L的检出率为36.9%。三氯卡班在青少年和成人中的检出率高于儿童，在非西班牙裔黑人中的检出率高于其他种族。在单变量分析中，对数肌酐、性别、年龄、种族和体表面积（BSA）与三氯卡班浓度高于第95百分位数的可能性显著相关。在多元回归模型中，BSA等于或高于中位数（≥1.86 m2）的人的尿浓度高于第95百分位数的可能性是其他人的2.43倍，非西班牙裔黑人和非西班牙裔白色人的尿浓度高于第95百分位数的可能性分别是“所有西班牙裔”的3.71倍和2.23倍。我们发现三氯卡班和三氯生（另一种常用的抗菌剂）的尿液浓度之间没有相关性。在所检查的人口统计学群体中观察到的差异可能反映了生理因素的差异（即，BSA）以及使用含有三氯卡班的个人护理产品。
Triclocarban is widely used as an antibacterial agent in personal care products, and the potential for human exposure exists. We present here the first nationally representative assessment of exposure to triclocarban among Americans ≥6 years of age who participated in the 2013–2014 National Health and Nutrition Examination Survey. We detected triclocarban at concentrations above 0.1 μg/L in 36.9% of 2686 urine samples examined. Triclocarban was detected more frequently in adolescents and adults than in children, and in non-Hispanic black compared to other ethnic groups. In univariate analysis, log-creatinine, sex, age, race, and body surface area (BSA) were significantly associated with the likelihood of having triclocarban concentrations above the 95th percentile. In multiple regression models, persons with BSA at or above the median (≥1.86 m2) were 2.43 times more likely than others, and non-Hispanic black and non-Hispanic white were 3.71 times and 2.23 times more likely than “all Hispanic,” respectively, to have urinary concentrations above the 95th percentile. We found no correlations between urinary concentrations of triclocarban and triclosan, another commonly used antibacterial agent. Observed differences among demographic groups examined may reflect differences in physiological factors (i.e., BSA) as well as use of personal care products containing triclocarban.
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