Differences in the mass and quality of the quadriceps with age and sex and their relationships with knee extension strength.
Differences in the mass and quality of the quadriceps with age and sex and their relationships with knee extension strength.
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DOI：
10.1002/jcsm.12715
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发表时间：
2021-08
期刊：
影响因子：
--
通讯作者：
Arai H
中科院分区：
文献类型：
--
作者：
Mizuno T;Matsui Y;Tomida M;Suzuki Y;Nishita Y;Tange C;Shimokata H;Imagama S;Otsuka R;Arai H
虽然肌肉质量评估目前被认为是诊断肌肉减少症的重要，但缺乏来自普通人群的数据。本研究使用大腿中部计算机断层扫描测量来评估股四头肌质量和质量的年龄相关和性别相关差异及其与膝关节伸展强度（KES）的关系。分析了520名日本人（273名男性和247名女性，平均年龄：63.1 ± 10.6岁）的横断面数据。分别使用四头肌横截面积（CSA）和计算机断层扫描值（CTV）评估质量和质量。评估了四种组成肌肉、肌间脂肪组织和整个四头肌面积（总四头肌+肌间脂肪组织），并按5个年龄组和性别对数据进行分层。为了评价年龄相关的下降，根据组成肌肉和性别对线性和二次方程进行拟合检验。520名参与者中有472名（254名男性和218名女性，平均年龄：62.3 ± 10.3）可以测量KES。然后使用年龄调整模型的多元线性回归分析来评价KES和四头肌测量值之间的关系。所有肌肉CSA和CTV均随年龄增长呈下降趋势（男性：所有P < 0.001;女性：股内侧肌CTV，P = 0.004;其他，P < 0.001）;肌间脂肪组织CSA未显示任何趋势（男性：P = 0.938;女性：P = 0.139），尽管其占整个股四头肌面积的百分比在男女中均呈上升趋势（P < 0.001）。男性在整个股四头肌区域（P = 0.016）、全部股四头肌（P = 0.021）、股内侧肌（P = 0.010）和股外侧肌（P = 0.038）以及所有CTV（股直肌，P = 0.044;其他，P < 0.001）的CSA呈二次下降。女性股直肌CTV呈二次方程（P = 0.031），但其他变量呈线性下降（P < 0.001）。股四头肌CSA和CTV与KES的发生有显著相关性（P < 0.001）。对于每块肌肉，股内侧肌的CSA（P < 0.001）和股中间肌（P = 0.001）与男性KES显著相关，而股内侧肌CSA股外侧肌CSA（P < 0.001）（P = 0.006），股直肌CSA（P = 0.020），和股中间肌CTV（P = 0.025）与女性KES显著相关。与年龄相关的股四头肌质量和质量变化因性别和组成肌肉而异。构成KES的肌肉在男性和女性之间是不同的。四头肌CSA和CTV测量可用于客观评估年龄相关和性别相关的肌肉退化和KES。
Although muscle quality evaluations are currently considered important for diagnosing sarcopenia, data from the general population are lacking. This study used mid‐thigh computed tomography measurements to evaluate age‐related and sex‐related differences in quadriceps femoris muscle quality and mass and their relationships with knee extension strength (KES). Cross‐sectional data from 520 Japanese individuals (273 men and 247 women, mean age: 63.1 ± 10.6 years) were analysed. Mass and quality were assessed using quadriceps cross‐sectional areas (CSAs) and computed tomography values (CTVs), respectively. The four constituent muscles, intermuscular adipose tissue, and entire quadriceps area (total quadriceps muscles + intermuscular adipose tissue) were assessed, and the data were stratified by five age groups and sex. To evaluate age‐related decline, linear and quadratic equations were tested for fit according to the constituent muscles and sex. KES could be measured in 472 of the 520 participants (254 men and 218 women, mean age: 62.3 ± 10.3). Multiple linear regression analyses with age‐adjusted models were then used for evaluating the relationships between KES and quadriceps measurements. All muscle CSAs and CTVs showed downward trends with age (men: P < 0.001 for all; women: vastus medialis CTV, P = 0.004; others, P < 0.001); the intermuscular adipose tissue CSA did not show any trend (men: P = 0.938; women: P = 0.139), although its percentage of the entire quadriceps area showed an upward trend in both sexes (P < 0.001). Men exhibited a quadratic decline in the CSAs for the entire quadriceps area (P = 0.016), total quadriceps muscles (P = 0.021), the vastus medialis (P = 0.010) and vastus lateralis (P = 0.038), and all CTVs (rectus femoris, P = 0.044; others, P < 0.001). Women exhibited a quadratic equation in the CTV for rectus femoris (P = 0.031), but a linear decline in the other variables (P < 0.001 for all). Both the total quadriceps muscles CSA and CTV were significantly associated with KES in both sexes (P < 0.001). For each muscle, the CSAs of the vastus medialis (P < 0.001) and vastus intermedius (P = 0.001) were significantly associated with KES in men, whereas the vastus medialis CSA (P < 0.001), vastus lateralis CSA (P = 0.006), rectus femoris CSA (P = 0.020), and vastus intermedius CTV (P = 0.025) were significantly associated with KES in women Age‐related quadriceps femoris changes in mass and quality differed by sex and the constituent muscles. The constituent muscles contributing to KES differed between men and women. Quadriceps CSA and CTV measurements are useful for objectively assessing age‐related and sex‐related muscle deterioration and KES.
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影响因子：
3.3
作者：
Goodpaster, BH;Carlson, CL;Newman, AB
通讯作者：
Newman, AB
DOI：
10.1152/ajpregu.00510.2007
发表时间：
2007-12-01
影响因子：
2.8
作者：
Devries, Michaela C.;Lowther, Stuart A.;Tarnopolsky, Mark A.
通讯作者：
Tarnopolsky, Mark A.
影响因子：
3.9
作者：
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通讯作者：
Carlier, Pierre G.
影响因子：
2.5
作者：
HENNEMAN, E;SOMJEN, G;CARPENTER, DO
通讯作者：
CARPENTER, DO
影响因子：
3.3
作者：
Gallagher, D;Visser, M;Heymsfield, SB
通讯作者：
Heymsfield, SB