Sex differences in sensitivity to prenatal and early childhood manganese exposure on neuromotor function in adolescents.
Sex differences in sensitivity to prenatal and early childhood manganese exposure on neuromotor function in adolescents.
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DOI：
10.1016/j.envres.2017.08.035
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发表时间：
2017-11
影响因子：
8.3
通讯作者：
Arora M
中科院分区：
文献类型：
--
作者：
Chiu YM;Claus Henn B;Hsu HL;Pendo MP;Coull BA;Austin C;Cagna G;Fedrighi C;Placidi D;Smith DR;Wright RO;Lucchini RG;Arora M
虽然研究表明锰（Mn）暴露可能与学龄儿童的神经发育有关，但关于产前和产后锰暴露以及儿童震颤或运动功能的信息有限。我们测量了锰水平的脱落的牙齿，代表产前，产后早期和累积的儿童暴露窗口，从195名儿童在意大利的牙本质。在11-14岁时进行追踪瞄准、Luria Nebraska运动电池以及来自计算机化自适应测试系统（CATSTOL）的震颤和摇摆系统。我们使用广义线性模型和广义加性模型研究了牙齿Mn（ln变换）与运动功能的关系，调整了年龄，性别和社会经济地位指数。还检查了性别对效应的影响。我们发现，在许多摇摆测试中（包括平均摇摆、横向摇摆、矢状摇摆、摇摆面积和摇摆强度），产前Mn较高与男孩身体稳定性较好相关，而Mn与女孩在所有这些指标上表现较差相关（Mn ×性别相互作用的所有p <0.05）。较高的产前锰也适度与更好的手/手指和眼手协调的男孩相比，女孩的性别分层分析，虽然交互模型没有达到统计学意义。另一方面，对于震颤，出生后早期较高的Mn与女孩中心频率增加相关（相互作用p <0.01），但出生后后期Mn水平增加与男孩中心频率增加相关（相互作用p =0.01）。这项研究，它使用了产前和儿童锰暴露的直接措施，建议在青少年的神经运动功能的早期生活锰暴露的性别特异性的关键窗口。性别特异性的关联可能是最强的全身稳定性的措施，其中的关键暴露窗口是在产前期间。
While studies have suggested that exposure to manganese (Mn) may be associated with neurodevelopment in school-age children, there is limited information on prenatal and postnatal Mn exposures and tremor or motor function in children. We measured Mn levels in dentine of shed teeth, representing prenatal, early postnatal, and cumulative childhood exposure windows, from 195 children in Italy. Pursuit Aiming, Luria Nebraska Motor Battery, as well as Tremor and Sway system from Computerized Adaptive Testing System (CATSYS) were administered at 11–14 years old. We examined the relationships of tooth Mn (ln-transformed) with motor function using generalized linear models and generalized additive models, adjusting for age, sex, and socioeconomic status index. Effect modification by sex was also examined. We found that higher prenatal Mn was associated with better body stability in boys in a number of sway tests (including mean sway, transversal sway, sagittal sway, sway area, and sway intensity), while Mn was associated with poorer performance in girls on all of these metrics (all p for Mn × sex interaction <0.05). Higher prenatal Mn was also modestly associated with better hand/finger and eye-hand coordination in boys compared to girls in sex-stratified analyses, although interaction models did not reach statistical significance. For tremor, on the other hand, higher early postnatal Mn was associated with increased center frequency in girls (p for interaction<0.01), but increased Mn level at the later postnatal period was associated with increased center frequency in boys (p for interaction=0.01). This study, which used a direct measure of prenatal and childhood Mn exposure, suggested sex-specific critical windows of early life Mn exposure in relation to neuromotor function in adolescents. The sex-specific associations might be strongest with measures of whole body stability, for which the critical exposure window was during the prenatal period.
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影响因子：
8.3
作者：
Lucas, E. L.;Bertrand, P.;Guazzetti, S.;Donna, F.;Peli, M.;Jursa, T. P.;Lucchini, R.;Smith, D. R.
通讯作者：
Smith, D. R.
DOI：
10.1186/1476-069x-13-87
发表时间：
2014-10-24
期刊：
Environmental health : a global access science source
影响因子：
--
作者：
Oulhote Y;Mergler D;Bouchard MF
通讯作者：
Bouchard MF
影响因子：
2.3
作者：
Kern, Cynthia H.;Stanwood, Gregg D.;Smith, Donald R.
通讯作者：
Smith, Donald R.
影响因子：
11.4
作者：
Gunier, Robert B.;Bradman, Asa;Jerrett, Michael;Smith, Donald R.;Harley, Kim G.;Austin, Christine;Vedar, Michelle;Arora, Manish;Eskenazi, Brenda
通讯作者：
Eskenazi, Brenda
影响因子：
10.4
作者：
Oulhote Y;Mergler D;Barbeau B;Bellinger DC;Bouffard T;Brodeur MÈ;Saint-Amour D;Legrand M;Sauvé S;Bouchard MF
通讯作者：
Bouchard MF