Paternal responsiveness is associated with, but not mediated by reduced neophobia in male California mice (Peromyscus californicus).
Paternal responsiveness is associated with, but not mediated by reduced neophobia in male California mice (Peromyscus californicus).
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DOI：
10.1016/j.physbeh.2012.05.012
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发表时间：
2012-08-20
影响因子：
2.9
通讯作者：
Saltzman, Wendy
中科院分区：
文献类型：
--
作者：
Chauke, Miyetani;de Jong, Trynke R.;Garland, Theodore, Jr.;Saltzman, Wendy
与怀孕和分娩相关的激素通过减少新生儿恐惧症、焦虑和压力反应而促进母性行为的发生。为了确定双亲雄性加州小鼠中父系行为的开始是否具有类似的关联（Peromyscus californicus），我们比较了父亲的反应，新对象测试（novel-object test），焦虑样行为（高架加迷宫，aerodynamic behavior）在孤立的处女（单独圈养），配对处女（与另一名男性圈养），准父亲（与怀孕的配偶圈养），和新的父亲（与配偶和幼崽一起圈养）。促肾上腺皮质激素释放激素（CRH）和Fos免疫反应性（IR）在脑组织暴露于捕食者气味应激或在基线条件下进行了定量。新父亲在自我测试中表现出比准父亲和孤立的处女更低的焦虑行为。在所有的住房条件下，应力升高Fos-IR下丘脑室旁核（PVN）。社会隔离减少整体（基线和压力引起的）Fos和共定位Fos/CRH-IR，并增加整体CRH-IR，在PVN。在杏仁核中央核，社会隔离增加应激诱导的CRH-IR和减少应激诱导的CRH神经元的激活。在所有的住房条件下，父亲行为的男性表现出更多的焦虑相关的行为比nonpaternal男性的CRH-或Fos-IR，但没有表现出差异。最后，潜伏期从事父亲的行为正相关的潜伏期，以接近一个新的对象。这些结果表明，初为人父并不能减少焦虑、恐新症或神经应激反应。然而，低水平的新恐惧症与父亲的反应有关，但不是必要的。
Hormones associated with pregnancy and parturition have been implicated in facilitating the onset of maternal behavior via reductions in neophobia, anxiety, and stress responsiveness. To determine whether the onset of paternal behavior has similar associations in biparental male California mice (Peromyscus californicus), we compared paternal responsiveness, neophobia (novel-object test), and anxiety-like behavior (elevated plus maze, EPM) in isolated virgins (housed alone), paired virgins (housed with another male), expectant fathers (housed with pregnant pairmate), and new fathers (housed with pairmate and pups). Corticotropin-releasing hormone (CRH) and Fos immunoreactivity (IR) were quantified in brain tissues following exposure to a predator-odor stressor or under baseline conditions. New fathers showed lower anxiety-like behavior than expectant fathers and isolated virgins in EPM tests. In all housing conditions, stress elevated Fos-IR in the hypothalamic paraventricular nucleus (PVN). Social isolation reduced overall (baseline and stress-induced) Fos- and colocalized Fos/CRH-IR, and increased overall CRH-IR, in the PVN. In the central nucleus of the amygdala, social isolation increased stress-induced CRH-IR and decreased stress-induced activation of CRH neurons. Across all housing conditions, paternally behaving males displayed more anxiety-related behavior than nonpaternal males in the EPM, but showed no differences in CRH- or Fos-IR. Finally, the latency to engage in paternal behavior was positively correlated with the latency to approach a novel object. These results suggest that being a new father does not reduce anxiety, neophobia, or neural stress responsiveness. Low levels of neophobia, however, were associated with, but not necessary for paternal responsiveness.
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影响因子：
56.9
作者：
FLEMING, A;VACCARINO, F;CHEE, P
通讯作者：
CHEE, P
影响因子：
2.9
作者：
FLEMING, AS;VACCARINO, F;LUEBKE, C
通讯作者：
LUEBKE, C
影响因子：
3.5
作者：
de Jong, Trynke R.;Chauke, Miyetani;Saltzman, Wendy
通讯作者：
Saltzman, Wendy
DOI：
10.1016/s0169-328x(01)00137-1
发表时间：
2001-07-13
期刊：
MOLECULAR BRAIN RESEARCH
影响因子：
--
作者：
da Costa, APC;Ma, XM;Aguilera, G
通讯作者：
Aguilera, G
影响因子：
4.1
作者：
Bridges, RS;Robertson, MC;Mann, PE
通讯作者：
Mann, PE