Hyperdirect connectivity of opercular speech network to the subthalamic nucleus.
Hyperdirect connectivity of opercular speech network to the subthalamic nucleus.
复制标题
尾部语音网络与丘脑下核的高导向连通性。
DOI:
10.1016/j.celrep.2022.110477
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发表时间:
2022-03-08
期刊:
影响因子:
8.8
通讯作者:
Richardson RM
中科院分区:
文献类型:
--
作者:
Jorge A;Lipski WJ;Wang D;Crammond DJ;Turner RS;Richardson RM
How the basal ganglia participate in the uniquely human behavior of speech is poorly understood, despite their known role in modulating critical aspects of cognitive and motor behavior. The subthalamic nucleus (STN) is well positioned to facilitate basal ganglia functions critical for speech. Using electrocorticography in patients undergoing awake deep brain stimulation (DBS) surgery, evidence is reported for a left opercular hyperdirect pathway in humans via stimulating the STN and examining antidromic-evoked activity in the left temporal, parietal, and frontal opercular cortex. These high-resolution cortical and subcortical mapping data provide evidence for hyperdirect connectivity between the inferior frontal gyrus and the STN. In addition, evoked potential data are consistent with the presence of monosynaptic projections from areas of the opercular ections may be unique to humans, evolving alongside the ability for speech. Using electrical stimulation of the subthalamic nucleus and simultaneous cortical recordings in individuals undergoing deep brain stimulation, Jorge et al. provide electrophysiological evidence for a hyperdirect pathway to the basal ganglia from cortical areas that control sensory and motor-planning aspects of speech.
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