Hyperdirect connectivity of opercular speech network to the subthalamic nucleus.

Hyperdirect connectivity of opercular speech network to the subthalamic nucleus.
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尾部语音网络与丘脑下核的高导向连通性。

DOI:
10.1016/j.celrep.2022.110477
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发表时间:
2022-03-08
期刊:
影响因子:
8.8
通讯作者:
Richardson RM
Richardson RM
中科院分区:
生物学1区
文献类型:
--
作者:
Jorge A;Lipski WJ;Wang D;Crammond DJ;Turner RS;Richardson RM

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尽管基底神经节在调节认知和运动行为的关键方面具有已知的作用,但人们对基底神经节如何参与人类独特的言语行为知之甚少。丘脑底核(subthalamic nucleus,简称丘脑底核)的位置有利于基底神经节发挥对语言至关重要的功能。在接受清醒脑深部电刺激(DBS)手术的患者中使用皮质电描记术,据报道,通过刺激小脑和检查左颞叶、顶叶和额叶鳃盖皮质的逆行诱发活动,有证据表明人类存在左鳃盖超直达通路。这些高分辨率的皮层和皮层下映射数据提供了证据,额下回和小脑之间的超直接连接。此外,诱发电位的数据是一致的存在单突触的预测,从地区的capercular ections可能是独特的人类,一起发展的语言能力。Jorge等人使用丘脑底核的电刺激和接受脑深部刺激的个体的同时皮层记录,提供了从控制言语的感觉和运动规划方面的皮层区域到基底神经节的超直接通路的电生理学证据。
How the basal ganglia participate in the uniquely human behavior of speech is poorly understood, despite their known role in modulating critical aspects of cognitive and motor behavior. The subthalamic nucleus (STN) is well positioned to facilitate basal ganglia functions critical for speech. Using electrocorticography in patients undergoing awake deep brain stimulation (DBS) surgery, evidence is reported for a left opercular hyperdirect pathway in humans via stimulating the STN and examining antidromic-evoked activity in the left temporal, parietal, and frontal opercular cortex. These high-resolution cortical and subcortical mapping data provide evidence for hyperdirect connectivity between the inferior frontal gyrus and the STN. In addition, evoked potential data are consistent with the presence of monosynaptic projections from areas of the opercular ections may be unique to humans, evolving alongside the ability for speech. Using electrical stimulation of the subthalamic nucleus and simultaneous cortical recordings in individuals undergoing deep brain stimulation, Jorge et al. provide electrophysiological evidence for a hyperdirect pathway to the basal ganglia from cortical areas that control sensory and motor-planning aspects of speech.
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