Neurodevelopmental hypothesis of schizophrenia.
Neurodevelopmental hypothesis of schizophrenia.
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DOI：
10.1192/bjp.bp.110.084384
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发表时间：
2011-03
期刊：
影响因子：
--
通讯作者：
Craddock N
中科院分区：
文献类型：
--
作者：
Owen MJ;O'Donovan MC;Thapar A;Craddock N
精神分裂症的神经发育假说提供了一个有价值的框架，使人们能够理解通常在青春期或成年早期表现为明显障碍的疾病至少部分是发育早期发生的事件的结果。然而，神经发育假说对疾病分类学概念的影响现在才能得到充分的理解。最近的研究表明，精神分裂症和综合征之间的遗传重叠，其中精神病理学在儿童时期表现出来，并且经常被归类为“神经发育障碍”，如自闭症谱系障碍，智力残疾和注意力缺陷多动障碍。这些发现挑战了目前诊断类别的病因学基础，并与频繁合并症的证据一起，表明我们应该将功能性精神病视为一组相关和重叠综合征的成员，这些综合征部分来自遗传和环境对大脑发育的影响，并与特定和一般认知功能障碍有关。这对未来的研究和精神科服务的配置具有重要意义。
The neurodevelopmental hypothesis of schizophrenia provided a valuable framework that allowed a condition that usually presents with frank disorder in adolescence or early adulthood to be understood at least in part as a consequence of events occurring early in development. However, the implications of the neurodevelopmental hypothesis for nosological conceptions of the disorder can only now be fully appreciated. Recent research indicates genetic overlap between schizophrenia and syndromes in which psychopathology is manifest in childhood and that are often grouped together as ‘ neurodevelopmental disorders’ such as autism-spectrum disorders, intellectual disability and attention-deficit hyperactivity disorder. These findings challenge the aetiological basis of current diagnostic categories and, together with evidence for frequent comorbidity, suggest that we should view the functional psychoses as members of a group of related and overlapping syndromes that result in part from a combination of genetic and environmental effects on brain development and that are associated with specific and general impairments of cognitive function. This has important implications for future research and for the configuration of psychiatric services.
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