Divergent Ventilatory and Blood Pressure Responses are Evident Following Repeated Daily Exposure to Mild Intermittent Hypoxia in Males with OSA and Hypertension.
Divergent Ventilatory and Blood Pressure Responses are Evident Following Repeated Daily Exposure to Mild Intermittent Hypoxia in Males with OSA and Hypertension.
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DOI：
10.3389/fphys.2022.897978
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发表时间：
2022
影响因子：
4
通讯作者：
中科院分区：
文献类型：
--
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简介：每日暴露于轻度间歇性缺氧（MIH）后，可增强静息分钟通气量和缺氧期间及之后的通气量。相反，每日暴露于MIH后，静息收缩压（SBP）降低。然而，目前尚不清楚每日暴露后的静息SBP降低是否与急性暴露于MIH期间和之后的SBP反应降低相关。 研究方法：患有阻塞性睡眠呼吸暂停（OSA）和高血压的参与者（n = 10）每天暴露于12次2分钟的MIH（氧饱和度-87%），持续15天。对照组（n = 6）暴露于假方案，在此期间压缩空气（即，FIO 2 = 0.21）的灵感，以代替MIH。 结果如下：低氧性舒张反应（HVR）和低氧性收缩压反应（HSBP）在低氧起始时从第一次到最后一次逐渐增加。（HVR：0.08 ± 0.02对比0.13 ± 0.02 L/min/mmHg，p = 0.03; HSBP：0.13 ± 0.04对比0.37 ± 0.06 mmHg/mmHg，p < 0.001）和最终（HVR：0.10 ± 0.01对比0.15 ± 0.03 L/min/mmHg，p = 0.03; HSBP：0.16 ± 0.03对比0.41 ± 0.34 mmHg/mmHg，p < 0.001）天。增加幅度在不同天之间无差异（p ≥ 0.83）。暴露于MIH后，与初始时的基线相比，每分钟通气量和SBP升高。（MV：16.70 ± 1.10 vs. 14.20 ± 0.28 L/min，p = 0.01; SBP：167.26 ± 4.43 vs. 151.13 ± 4.56 mmHg，p < 0.001）和最终（MV：17.90 ± 1.25 vs. 15.40 ± 0.77 L/min，p = 0.01; SBP：156.24 ± 3.42 vs. 137.18 ± 4.17 mmHg，p < 0.001）天。两天的升高幅度相似（MV：3.68 ± 1.69 vs. 3.22 ± 1.27 L/min，SBP：14.83 ± 2.64 vs. 14.28 ± 1.66 mmHg，p ≥ 0.414）。尽管存在这些相似性，但基线时和MIH方案期间其他时间点的血压在最后一天与初始日相比降低（p ≤ 0.005）。 结论：急性MIH期间和之后的呼吸和血压反应在暴露的最初和最后一天是相似的。或者，血压下调，而通气在所有时间点相似（即，基线、MIH期间和之后）。
Introduction: Resting minute ventilation and ventilation during and following hypoxia may be enhanced following daily exposure to mild intermittent hypoxia (MIH). In contrast, resting systolic blood pressure (SBP) is reduced following daily exposure to MIH. However, it is presently unknown if the reduction in resting SBP following daily exposure, is coupled with reduced SBP responses during and after acute exposure to MIH. Methods: Participants with obstructive sleep apnea (OSA) and hypertension (n = 10) were exposed to twelve 2-min bouts of MIH (oxygen saturation—87%)/day for 15 days. A control group (n = 6) was exposed to a sham protocol during which compressed air (i.e., FIO2 = 0.21) was inspired in place of MIH. Results: The hypoxic ventilatory response (HVR) and hypoxic systolic blood pressure response (HSBP) increased from the first to the last hypoxic episode on the initial (HVR: 0.08 ± 0.02 vs. 0.13 ± 0.02 L/min/mmHg, p = 0.03; HSBP: 0.13 ± 0.04 vs. 0.37 ± 0.06 mmHg/mmHg, p < 0.001) and final (HVR: 0.10 ± 0.01 vs. 0.15 ± 0.03 L/min/mmHg, p = 0.03; HSBP: 0.16 ± 0.03 vs. 0.41 ± 0.34 mmHg/mmHg, p < 0.001) day. The magnitude of the increase was not different between days (p ≥ 0.83). Following exposure to MIH, minute ventilation and SBP was elevated compared to baseline on the initial (MV: 16.70 ± 1.10 vs. 14.20 ± 0.28 L/min, p = 0.01; SBP: 167.26 ± 4.43 vs. 151.13 ± 4.56 mmHg, p < 0.001) and final (MV: 17.90 ± 1.25 vs. 15.40 ± 0.77 L/min, p = 0.01; SBP: 156.24 ± 3.42 vs. 137.18 ± 4.17 mmHg, p < 0.001) day. The magnitude of the increases was similar on both days (MV: 3.68 ± 1.69 vs. 3.22 ± 1.27 L/min, SBP: 14.83 ± 2.64 vs. 14.28 ± 1.66 mmHg, p ≥ 0.414). Despite these similarities, blood pressure at baseline and at other time points during the MIH protocol was reduced on the final compared to the initial day (p ≤ 0.005). Conclusion: The ventilatory and blood pressure responses during and following acute MIH were similar on the initial and final day of exposure. Alternatively, blood pressure was down regulated, while ventilation was similar at all time points (i.e., baseline, during and following MIH) after daily exposure to MIH.
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影响因子：
3.3
作者：
Gerst, David G., III;Yokhana, Sanar S.;Mateika, Jason H.
通讯作者：
Mateika, Jason H.
DOI：
10.1016/0165-1838(88)90078-1
发表时间：
1988-08-01
期刊：
JOURNAL OF THE AUTONOMIC NERVOUS SYSTEM
影响因子：
--
作者：
PAGANI, M;MALFATTO, G;MALLIANI, A
通讯作者：
MALLIANI, A
影响因子：
3.3
作者：
Cutler, MJ;Swift, NM;Smith, ML
通讯作者：
Smith, ML
影响因子：
8.3
作者：
Costa, F;Biaggioni, I
通讯作者：
Biaggioni, I
影响因子：
4.9
作者：
Haider, Thomas;Casucci, Gaia;Bernardi, Luciano
通讯作者：
Bernardi, Luciano