Antioxidants as potential therapeutics for neuropsychiatric disorders.
Antioxidants as potential therapeutics for neuropsychiatric disorders.
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DOI：
10.1016/j.pnpbp.2012.10.017
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发表时间：
2013-10-01
影响因子：
5.6
通讯作者：
Pillai, Anilkumar
中科院分区：
文献类型：
--
作者：
Pandya, Chirayu D.;Howell, Kristy R.;Pillai, Anilkumar
氧化应激与许多神经精神疾病的病理生理有关，如精神分裂症、双相情感障碍、重度抑郁症等。遗传和非遗传因素均可导致精神疾病患者细胞活性氧水平升高，超出抗氧化防御机制的能力。这些因素触发氧化细胞损伤脂质，蛋白质和DNA，导致异常的神经生长和分化。因此，新的治疗策略，如补充抗氧化剂可以有效的长期治疗管理神经精神疾病。使用抗氧化剂和PUFAs作为治疗神经精神疾病的补充已经提供了一些有希望的结果。同时，人们应该谨慎使用抗氧化剂，因为过量的抗氧化剂会危险地干扰活性氧的一些保护功能。本文将概述使用抗氧化剂治疗精神疾病的潜在策略和结果。
Oxidative stress has been implicated in the pathophysiology of many neuropsychiatric disorders such as schizophrenia, bipolar disorder, major depression etc. Both genetic and nongenetic factors have been found to cause increased cellular levels of reactive oxygen species beyond the capacity of antioxidant defense mechanism in patients of psychiatric disorders. These factors trigger oxidative cellular damage to lipids, proteins and DNA, leading to abnormal neural growth and differentiation. Therefore, novel therapeutic strategies such as supplementation with antioxidants can be effective for long-term treatment management of neuropsychiatric disorders. The use of antioxidants and PUFAs as supplements in the treatment of neuropsychiatric disorders has provided some promising results. At the same time, one should be cautious with the use of antioxidants since excessive antioxidants could dangerously interfere with some of the protective functions of reactive oxygen species. The present article will give an overview of the potential strategies and outcomes of using antioxidants as therapeutics in psychiatric disorders.
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