Organization of the gravity-sensing system in zebrafish.
Organization of the gravity-sensing system in zebrafish.
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DOI：
10.1038/s41467-022-32824-w
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发表时间：
2022-08-27
影响因子：
16.6
通讯作者：
中科院分区：
文献类型：
--
作者：
运动电路的发育顺序是从控制快运动到控制慢运动。在这里，我们检查上游感觉电路是否由类似的原则组织。利用斑马鱼幼虫的连续切片电子显微镜，我们生成了从内耳到脑干的重力感应（电路）系统的完整地图。我们发现感觉调谐和发育顺序都是前庭地形的组织原则。从毛细胞到传入神经的背侧侧神经支配模式在脑室神经节中创建了解剖学上推断的定向调谐图，形成了吻侧和尾侧倾斜的分离通路。此外，神经节的中外侧轴与发育序列和神经元时间动力学有关。早期出生的携带相位信息的通路优先激活快速逃逸回路，而晚期出生的携带张力信号的通路则激活较慢的姿势和动眼肌回路。这些结果表明，前庭回路是通过调整方向和动态来组织的，并使它们与下游的运动回路和行为保持一致。感官系统在发育过程中是如何组织的尚不清楚。本文作者利用电子显微镜对斑马鱼的重力感应系统进行了研究，发现方向调谐和发育年龄是前庭感觉向运动控制转变的组织原则。
Motor circuits develop in sequence from those governing fast movements to those governing slow. Here we examine whether upstream sensory circuits are organized by similar principles. Using serial-section electron microscopy in larval zebrafish, we generated a complete map of the gravity-sensing (utricular) system spanning from the inner ear to the brainstem. We find that both sensory tuning and developmental sequence are organizing principles of vestibular topography. Patterned rostrocaudal innervation from hair cells to afferents creates an anatomically inferred directional tuning map in the utricular ganglion, forming segregated pathways for rostral and caudal tilt. Furthermore, the mediolateral axis of the ganglion is linked to both developmental sequence and neuronal temporal dynamics. Early-born pathways carrying phasic information preferentially excite fast escape circuits, whereas later-born pathways carrying tonic signals excite slower postural and oculomotor circuits. These results demonstrate that vestibular circuits are organized by tuning direction and dynamics, aligning them with downstream motor circuits and behaviors. How sensory systems are organized during development remains unclear. Here, the authors used electron microscopy to examine the gravity-sensing system in zebrafish, finding that directional tuning and developmental age are organizing principles of the transformation from vestibular sensation to motor control.
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影响因子：
5.7
作者：
Bagnall MW;Schoppik D
通讯作者：
Schoppik D
影响因子：
2.5
作者：
FERNANDEZ, C;GOLDBERG, JM
通讯作者：
GOLDBERG, JM
DOI：
10.1073/pnas.96.13.7558
发表时间：
1999-06-22
影响因子：
11.1
作者：
Alexandre, D;Ghysen, A
通讯作者：
Ghysen, A
影响因子：
9.2
作者：
Ehrlich, David E.;Schoppik, David
通讯作者：
Schoppik, David
影响因子：
2.5
作者：
BAIRD, RA;SCHUFF, NR
通讯作者：
SCHUFF, NR