Amygdala-mediated enhancement of memory for specific events depends on the hippocampus.
Amygdala-mediated enhancement of memory for specific events depends on the hippocampus.
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DOI：
10.1016/j.nlm.2013.10.020
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发表时间：
2014-01
影响因子：
2.7
通讯作者：
Manns, Joseph R.
中科院分区：
文献类型：
--
作者：
Bass, David I.;Nizam, Zainab G.;Partain, Kristin N.;Wang, Arick;Manns, Joseph R.
关键词：
情感事件通常比中性事件更容易被记住，这是一种依赖于杏仁核的情感显着性的记忆优先级排序。对大鼠的研究表明，直接激活杏仁核基底外侧复合体（BLA）可以增强对中性事件的记忆，如果激活时间短暂且具有时间目标性，则可以以有利于对特定事件的记忆的方式做到这一点。在事件特异性记忆增强的情况下，BLA激活的基本靶点尚不清楚，但已知海马体接收来自BLA的直接投射并支持对事件的记忆。在本研究中，大鼠接受蝇蕈醇，GABAA受体激动剂，或生理盐水到海马体的平衡输注之前，进行一种新的对象识别记忆任务，在此期间，最初遇到的一些对象，随后立即进行短暂的电刺激BLA。当在盐水条件下测试1天后的记忆时，大鼠很好地记住了这些物体，但是对于最初遇到的物体没有随后的BLA刺激没有显示出记忆。相反，在蝇蕈醇条件下未观察到BLA刺激对记忆的益处。结果表明，BLA的短暂激活可以通过增强对某些物体遭遇的记忆来优先考虑事件的记忆，而不是其他物体，这种对记忆的益处取决于杏仁核和海马体之间的相互作用。
Emotional events are often remembered better than neutral events, a type of memory prioritization by affective salience that depends on the amygdala. Studies with rats have indicated that direct activation of the basolateral complex of the amygdala (BLA) can enhance memory for neutral events, and if the activation is brief and temporally targeted, can do so in way that benefits memories for specific events. The essential targets of BLA activation in the case of event-specific memory enhancement were unknown, but the hippocampus was known to receive direct projections from the BLA and to support memory for events. In the present study, rats received counterbalanced infusions of either muscimol, a GABAA receptor agonist, or saline into the hippocampus prior to performing a novel object recognition memory task during which initial encounters with some of the objects were immediately followed by brief electrical stimulation to the BLA. When memory was tested 1 day later in the saline condition, rats remembered these objects well but showed no memory for objects for which the initial encounter had not been followed by BLA stimulation. In contrast, no benefit to memory of BLA stimulation was observed in the muscimol condition. The results indicated that brief activation of the BLA can prioritize memories for events by enhancing memory for some object encounters but not others and that this benefit to memory depends on interactions between the amygdala and the hippocampus.
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