Circadian timing of ethanol exposure exerts enduring effects on subsequent ad libitum consumption in C57 mice.
Circadian timing of ethanol exposure exerts enduring effects on subsequent ad libitum consumption in C57 mice.
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DOI：
10.1111/j.1530-0277.2009.00954.x
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发表时间：
2009-07
期刊：
影响因子：
--
通讯作者：
Gorman MR
中科院分区：
文献类型：
--
作者：
Trujillo JL;Roberts AJ;Gorman MR
小鼠自愿摄入乙醇有一个每日节律，夜间摄入量最大，白天摄入量最低。长期乙醇自我管理的发展和控制的作用，每天的时间乙醇暴露被忽视。本研究使用C57 BL/6 J小鼠来检查这些问题。将小鼠在夜间或白天重复暴露于10%乙醇中2小时，持续数周。随后，在相反的时间（实验1）或每天24小时（实验1和2）提供乙醇。舔传感器记录实验2中的饮水活动的模式。晚上接触乙醇的小鼠比白天接触乙醇的小鼠喝得更多。当时间表颠倒时，既往病史并不影响乙醇摄入量。在24小时暴露条件下，有夜间饮酒史的小鼠比白天饮酒的小鼠消耗更多。饮酒的昼夜节律模式没有改变。这些结果表明，每天乙醇暴露的时间发挥持久的影响，自我管理的乙醇在小鼠。了解昼夜节律如何调节乙醇的消耗可能对修改随后的摄入量有价值。
There is a daily rhythm in the voluntary intake of ethanol in mice, with greatest consumption in the early night and lowest intake during the day. The role of daily timing of ethanol exposure on the development and control of long-term ethanol self-administration has been neglected. The present study examines these issues using C57BL/6J mice. Mice were repeatedly exposed to 10% ethanol for 2 h early in the night or day for several weeks. Subsequently, ethanol was available at the opposite time (Expt 1) or 24 h daily (Expts 1 and 2). Lick sensors recorded the patterns of drinking activity in Experiment 2. Mice exposed to ethanol during the night drink more than mice exposed during the day. Prior history did not affect ethanol intake when the schedule was reversed. Under 24 hour exposure conditions, mice with a history of drinking during the night consumed significantly more than mice drinking during the day. The circadian patterns of drinking were not altered. These results demonstrate that the daily timing of ethanol exposure exerts enduring effects of self-administration of ethanol in mice. Understanding how circadian rhythms regulate ethanol consumption may be valuable for modifying subsequent intake.
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影响因子：
2.8
作者：
Danel, T;Jeanson, R;Touitou, Y
通讯作者：
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影响因子：
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作者：
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通讯作者：
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作者：
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DOI：
10.1111/j.1530-0277.2006.00248.x
发表时间：
2006-12-01
影响因子：
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作者：
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通讯作者：
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影响因子：
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作者：
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通讯作者：
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