Antioxidant effects of vitamins in type 2 diabetes: a meta-analysis of randomized controlled trials.
Antioxidant effects of vitamins in type 2 diabetes: a meta-analysis of randomized controlled trials.
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DOI：
10.1186/s13098-018-0318-5
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发表时间：
2018
影响因子：
4.8
通讯作者：
Pontarolo R
中科院分区：
文献类型：
--
作者：
Balbi ME;Tonin FS;Mendes AM;Borba HH;Wiens A;Fernandez-Llimos F;Pontarolo R
维生素是具有抗氧化潜力的必需微量营养素，可为慢性病患者提供补充治疗。我们的目的是评估维生素补充对2型糖尿病患者抗氧化状态和血糖指数的影响。我们进行了一项系统回顾和荟萃分析。在PubMed、Scopus和Web of Science中进行了电子检索（2017年12月）。随机对照试验评估任何维生素或维生素复合物补充剂对抗氧化状态的影响作为主要结果。审议的结果如下：丙二醛（MDA）的减少、谷胱甘肽过氧化物酶（GPx）的增加、总抗氧化能力（TAC）的变化、超氧化物歧化酶-SOD和硫代巴比妥酸反应物质（TBARS）的增加。还评价了血糖控制的结果。使用软件Review Manager 5.3进行成对荟萃分析。30项试验符合纳入标准，但只有12项可纳入抗氧化剂结局的荟萃分析。最常被研究的维生素是B、C、D和E。与安慰剂相比，维生素E与血糖和糖化血红蛋白显著降低相关，而与安慰剂相比，维生素C和E主要与MDA和TBARS降低以及GPx、SOD和TAC升高相关。然而，这一领域的成果报告仍然不一致（例如，由于缺乏标准措施）。补充维生素E可能是控制糖尿病并发症和增强抗氧化能力的有价值的策略。其他微量营养素的作用应在更大规模和精心设计的试验中进一步研究，以适当地将这些补充疗法应用于临床实践。本文的在线版本（10.1186/s13098-018-0318-5）包含补充材料，可供授权用户使用。
Vitamins are essential micronutrients with antioxidant potential that may provide a complementary treatment for patients with chronic diseases. Our aim was to assess the effect of vitamin supplementation on the antioxidant status and glycemic index of type 2 diabetes mellitus patients. We performed a systematic review with meta-analyses. Electronic searches were conducted in PubMed, Scopus, and Web of Science (December 2017). Randomized controlled trials evaluating the effect of any vitamin or vitamin complex supplementation on antioxidant status as primary outcome were included. The outcomes considered were: reduction of malondialdehyde (MDA); augmentation of glutathione peroxidase (GPx); changes in total antioxidant capacity (TAC), enhance in superoxide dismutase enzyme—SOD, and thiobarbituric acid reactive substances (TBARS). Outcomes of glycemic control were also evaluated. Pairwise meta-analyses were performed using software Review Manager 5.3. Thirty trials fulfilled the inclusion criteria, but only 12 could be included in the meta-analyses of antioxidant outcomes. The most commonly studied vitamins were B, C, D and E. Vitamin E was related to significant reduction of blood glucose as well as glycated hemoglobin compared to placebo, while both vitamins C and E were mainly associated with reducing MDA and TBARS and elevating GPx, SOD and TAC, compared to placebo. However, outcome reports in this field are still inconsistent (e.g. because of a lack of standard measures). Supplementation of vitamin E may be a valuable strategy for controlling diabetes complications and enhancing antioxidant capacity. The effects of other micronutrients should be further investigated in larger and well-designed trials to properly place these complementary therapies in clinical practice. The online version of this article (10.1186/s13098-018-0318-5) contains supplementary material, which is available to authorized users.
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DOI：
10.1080/07315724.2011.10719962
发表时间：
2011-06-01
影响因子：
3.5
作者：
Aghamohammadi, Vahide;Gargari, Bahram Pourghassem;Aliasgharzadeh, Akbar
通讯作者：
Aliasgharzadeh, Akbar
影响因子：
5.4
作者：
Fenercioglu, A. Kutan;Saler, T.;Altuntas, Y.
通讯作者：
Altuntas, Y.
影响因子：
2.4
作者：
Dalan R;Liew H;Assam PN;Chan ES;Siddiqui FJ;Tan AW;Chew DE;Boehm BO;Leow MK
通讯作者：
Leow MK
影响因子：
5.9
作者：
Gariballa S;Afandi B;Abu Haltem M;Yassin J;Alessa A
通讯作者：
Alessa A
影响因子：
5.9
作者：
Church, TS;Earnest, CP;Kampert, JB
通讯作者：
Kampert, JB