Immunology of Aging: the Birth of Inflammaging.
Immunology of Aging: the Birth of Inflammaging.
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DOI：
10.1007/s12016-021-08899-6
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发表时间：
2023-04
影响因子：
9.1
通讯作者：
Franceschi C
中科院分区：
文献类型：
--
作者：
Fulop T;Larbi A;Pawelec G;Khalil A;Cohen AA;Hirokawa K;Witkowski JM;Franceschi C
炎症的概念由Franceschi教授于2000年提出。这是一个进化的，或者说是一个革命性的概念化的免疫变化，以应对终身的压力。这种概念化允许将终身促炎过程视为最终可能导致有益或有害后果的适应。这种二分法受到遗传和环境的影响。取决于哪种方式在个体中占主导地位，结果可能是健康的长寿或负担着与衰老有关的疾病的病理性衰老。炎症的概念也揭示了衰老的复杂性和系统性。因此，这种概念化为考虑与年龄有关的过程的复杂性开辟了道路，这意味着不仅要考虑过程，还要考虑所有的反过程。它还开辟了向原始概念添加新概念的途径，从而更好地理解炎症和衰老本身的本质。最后，它显示了潜在的多模式干预措施的方式，涉及一个整体的方法，以优化衰老过程，实现健康的长寿。
The inflammaging concept was introduced in 2000 by Prof. Franceschi. This was an evolutionary or rather a revolutionary conceptualization of the immune changes in response to a lifelong stress. This conceptualization permitted to consider the lifelong proinflammatory process as an adaptation which could eventually lead to either beneficial or detrimental consequences. This dichotomy is influenced by both the genetics and the environment. Depending on which way prevails in an individual, the outcome may be healthy longevity or pathological aging burdened with aging-related diseases. The concept of inflammaging has also revealed the complex, systemic nature of aging. Thus, this conceptualization opens the way to consider age-related processes in their complexity, meaning that not only the process but also all counter-processes should be considered. It has also opened the way to add new concepts to the original one, leading to better understanding of the nature of inflammaging and of aging itself. Finally, it showed the way towards potential multimodal interventions involving a holistic approach to optimize the aging process towards a healthy longevity.
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