Macromolecular Proton Fraction as a Myelin Biomarker: Principles, Validation, and Applications.
Macromolecular Proton Fraction as a Myelin Biomarker: Principles, Validation, and Applications.
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DOI：
10.3389/fnins.2022.819912
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发表时间：
2022
影响因子：
4.3
通讯作者：
Yarnykh VL
中科院分区：
文献类型：
--
作者：
Kisel AA;Naumova AV;Yarnykh VL
大分子质子分数（MPF）是描述磁化转移（MT）效应的定量MRI参数，定义为约束分子运动的生物大分子参与与水质子磁交叉弛豫的相对质子数量。MPF作为髓磷脂的生物标志物在过去十年中引起了极大的兴趣。这篇小型综述的目的是提供一个简短而全面的MPF制图方法，组织学验证研究，以及MPF在神经科学中的应用。从技术上讲，可以使用各种定量MT方法获得MPF图。其中一些使临床合理的扫描时间和分辨率。最近的研究证明了使用标准临床MRI脉冲序列进行MPF定位的可行性，从而大大提高了方法的可用性。在动物模型中进行的一些研究表明，MPF与髓磷脂的组织学标记物之间存在很强的相关性，潜在混杂因素的影响很小。组织学研究证实了MPF监测脱髓鞘和再髓鞘形成的能力。MPF的临床应用主要集中在多发性硬化症，该方法为白质和灰质病理提供了新的见解。此外，一些研究使用MPF来研究髓磷脂在其他神经和精神疾病中的作用。强积金应用的另一个有前景的领域是大脑发育研究。MPF证明了在产前脑成熟和青春期髓磷脂发育的早期阶段定量表征髓鞘形成的能力。综上所述，MPF成像技术为临床前和临床神经科学的各种应用提供了技术成熟和全面验证的髓磷脂成像技术。
Macromolecular proton fraction (MPF) is a quantitative MRI parameter describing the magnetization transfer (MT) effect and defined as a relative amount of protons bound to biological macromolecules with restricted molecular motion, which participate in magnetic cross-relaxation with water protons. MPF attracted significant interest during past decade as a biomarker of myelin. The purpose of this mini review is to provide a brief but comprehensive summary of MPF mapping methods, histological validation studies, and MPF applications in neuroscience. Technically, MPF maps can be obtained using a variety of quantitative MT methods. Some of them enable clinically reasonable scan time and resolution. Recent studies demonstrated the feasibility of MPF mapping using standard clinical MRI pulse sequences, thus substantially enhancing the method availability. A number of studies in animal models demonstrated strong correlations between MPF and histological markers of myelin with a minor influence of potential confounders. Histological studies validated the capability of MPF to monitor both demyelination and re-myelination. Clinical applications of MPF have been mainly focused on multiple sclerosis where this method provided new insights into both white and gray matter pathology. Besides, several studies used MPF to investigate myelin role in other neurological and psychiatric conditions. Another promising area of MPF applications is the brain development studies. MPF demonstrated the capabilities to quantitatively characterize the earliest stage of myelination during prenatal brain maturation and protracted myelin development in adolescence. In summary, MPF mapping provides a technically mature and comprehensively validated myelin imaging technology for various preclinical and clinical neuroscience applications.
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影响因子：
5.7
作者：
Corrigan NM;Yarnykh VL;Hippe DS;Owen JP;Huber E;Zhao TC;Kuhl PK
通讯作者：
Kuhl PK
影响因子：
3.3
作者：
Deoni, Sean C. L.;Rutt, Brian K.;Jones, Derek K.
通讯作者：
Jones, Derek K.
影响因子：
2.8
作者：
Anisimov, Nikolay V.;Pavlova, Olga S.;Yarnykh, Vasily L.
通讯作者：
Yarnykh, Vasily L.
影响因子：
3.3
作者：
Deoni, SCL;Peters, TM;Rutt, BK
通讯作者：
Rutt, BK
影响因子：
2.4
作者：
Garcia, Meritxell;Gloor, Monika;Stippich, Christoph
通讯作者：
Stippich, Christoph