Anatomy Based Networks and Topology Alteration in Seizure-Related Cognitive Outcomes.
Anatomy Based Networks and Topology Alteration in Seizure-Related Cognitive Outcomes.
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癫痫相关认知结果中基于解剖学的网络和拓扑改变
DOI：
10.3389/fnana.2018.00025
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发表时间：
2018
影响因子：
2.9
通讯作者：
Feng L
中科院分区：
文献类型：
--
作者：
Wu Q;Zhao CW;Long Z;Xiao B;Feng L
癫痫是一种阵发性神经系统疾病，其特征是复发性和无端癫痫发作，影响全球约5000万人。癫痫发作引起的认知功能障碍是癫痫和癫痫综合征的严重并发症，降低了患者的生活质量。癫痫发作，沿着伴随组织病理学和病理生理学变化，与认知共病相关。成像技术和计算的进步允许可视化神经网络中的解剖和拓扑变化。包括海马、杏仁核、皮质、胼胝体（CC）、小脑和白色物质（WM）在内的解剖学组成部分是癫痫发作和认知相关拓扑网络的基本组成部分。对这些结构及其亚结构的损伤导致癫痫症状和认知功能障碍的恶化。在这篇综述文章中，我们调查了大脑不同区域以及不同癫痫和癫痫综合征的结构，网络变化和拓扑改变，并讨论了这些变化可能意味着与这些疾病状态相关的认知结果。
Epilepsy is a paroxysmal neurological disorder characterized by recurrent and unprovoked seizures affecting approximately 50 million people worldwide. Cognitive dysfunction induced by seizures is a severe comorbidity of epilepsy and epilepsy syndromes and reduces patients’ quality of life. Seizures, along with accompanying histopathological and pathophysiological changes, are associated with cognitive comorbidities. Advances in imaging technology and computing allow anatomical and topological changes in neural networks to be visualized. Anatomical components including the hippocampus, amygdala, cortex, corpus callosum (CC), cerebellum and white matter (WM) are the fundamental components of seizure- and cognition-related topological networks. Damage to these structures and their substructures results in worsening of epilepsy symptoms and cognitive dysfunction. In this review article, we survey structural, network changes and topological alteration in different regions of the brain and in different epilepsy and epileptic syndromes, and discuss what these changes may mean for cognitive outcomes related to these disease states.
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影响因子：
6.1
作者：
Hernan AE;Holmes GL;Isaev D;Scott RC;Isaeva E
通讯作者：
Isaeva E
影响因子：
5
作者：
Bandopadhyay R;Liu JY;Sisodiya SM;Thom M
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Thom M
影响因子：
4.8
作者：
Bonilha L;Tabesh A;Dabbs K;Hsu DA;Stafstrom CE;Hermann BP;Lin JJ
通讯作者：
Lin JJ
影响因子：
5.3
作者：
Alarcon, JM;Barco, A;Kandel, ER
通讯作者：
Kandel, ER
影响因子：
2.6
作者：
DuBois, J. M.;Devinsky, O.;Thesen, T.
通讯作者：
Thesen, T.