The First "Hit" to the Endocannabinoid System? Associations Between Prenatal Cannabis Exposure and Frontolimbic White Matter Pathways in Children.
The First "Hit" to the Endocannabinoid System? Associations Between Prenatal Cannabis Exposure and Frontolimbic White Matter Pathways in Children.
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DOI：
10.1016/j.bpsgos.2023.09.005
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发表时间：
2024-01
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影响因子：
--
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大麻是美国孕妇中最常使用的联邦非法物质。然而，新出现的临床前数据表明，很大一部分大麻成分，例如 Δ9-四氢大麻酚及其生物活性代谢物，很容易穿过胎盘并积聚在胎儿大脑中，扰乱神经发育。最近使用青少年大脑认知发展（ABCD）研究队列的研究发现，产前大麻暴露（PCE）与儿童更大的神经行为问题以及更低的灰质和白质总量有关。在这里，我们研究了 PCE 对额叶白质通路的影响，这些通路对于认知和情感相关功能至关重要，显示出高密度的大麻素受体，并且在神经快速发育的其他时期（例如青春期）容易受到大麻暴露的影响。这项研究包括来自 ABCD 研究队列的 11,530 名儿童（平均 ± 标准差年龄 = 118.99 ± 7.49 个月；47% 为女性）。使用线性混合效应模型来检查护理人员报告的 PCE 对 10 条额边缘通路（每个半球 5 条）的分数各向异性的影响。 PCE 与右侧穹窿 (β = −0.005，p < .001) 和左侧 (β = −0.003，p = .007) 较低的分数各向异性相关，并且在调整各种协变量、多重比较、所有纤维的分数各向异性并仅使用质量控制队列后，这些结果仍然显着。总之，我们证明了 PCE 对儿童时期白质完整性的影响虽小但可靠，特别是在穹窿中，它在情绪和记忆相关过程中发挥着至关重要的作用。未来的研究需要了解大脑结构或功能的微小变化对神经发育和神经行为问题风险的影响。
Cannabis is the most used federally illicit substance among pregnant people in the United States. However, emerging preclinical data show that a significant portion of cannabis constituents, such as Δ9-tetrahydrocannabinol and its bioactive metabolites, readily cross the placenta and accumulate in the fetal brain, disrupting neurodevelopment. Recent research using the Adolescent Brain Cognitive Development (ABCD) Study cohort has linked prenatal cannabis exposure (PCE) to greater neurobehavioral problems and lower total gray and white matter volume in children. Here, we examined the impact of PCE on frontolimbic white matter pathways that are critical for cognitive- and emotion-related functioning, show a high density of cannabinoid receptors, and are susceptible to cannabis exposure during other periods of rapid neurodevelopment (e.g., adolescence). This study included 11,530 children (mean ± SD age = 118.99 ± 7.49 months; 47% female) from the ABCD Study cohort. Linear mixed-effects models were used to examine the effects of caregiver-reported PCE on fractional anisotropy of 10 frontolimbic pathways (5 per hemisphere). PCE was associated with lower fractional anisotropy of the right (β = −0.005, p < .001) and left (β = −0.003, p = .007) fornix, and these results remained significant after adjusting for a variety of covariates, multiple comparisons, fractional anisotropy of all fibers, and using a quality-control cohort only. In sum, we demonstrated small, yet reliable, effects of PCE on white matter integrity during childhood, particularly in the fornix, which plays a crucial role in emotion- and memory-related processes. Future studies are needed to understand the impacts of small changes in brain structure or function on neurodevelopment and risk of neurobehavioral problems.
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影响因子：
6.7
作者：
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影响因子：
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DOI：
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发表时间：
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Casey BJ;Cannonier T;Conley MI;Cohen AO;Barch DM;Heitzeg MM;Soules ME;Teslovich T;Dellarco DV;Garavan H;Orr CA;Wager TD;Banich MT;Speer NK;Sutherland MT;Riedel MC;Dick AS;Bjork JM;Thomas KM;Chaarani B;Mejia MH;Hagler DJ Jr;Daniela Cornejo M;Sicat CS;Harms MP;Dosenbach NUF;Rosenberg M;Earl E;Bartsch H;Watts R;Polimeni JR;Kuperman JM;Fair DA;Dale AM;ABCD Imaging Acquisition Workgroup
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