Effects of prenatal cannabis exposure on developmental trajectory of cognitive ability and brain volumes in the adolescent brain cognitive development (ABCD) study.
Effects of prenatal cannabis exposure on developmental trajectory of cognitive ability and brain volumes in the adolescent brain cognitive development (ABCD) study.
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DOI：
10.1016/j.dcn.2023.101209
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发表时间：
2023-04
影响因子：
4.7
通讯作者：
Mizuno, Yoshifumi
中科院分区：
文献类型：
--
作者：
Hiraoka, Daiki;Makita, Kai;Hamatani, Sayo;Tomoda, Akemi;Mizuno, Yoshifumi
虽然怀孕期间使用大麻的情况正在广泛增加，但大麻对发育轨迹的影响，例如其在怀孕期间的影响在不同时间点之间是否保持不变或逐渐增加，尚不清楚。这项研究旨在研究怀孕期间使用大麻是否会影响认知和脑容量的变化过程。对纵向测量的两个时间点的数据进行分析。我们使用了青少年大脑和认知发展研究的数据。参与者包括11876名9-11岁的儿童，基线时参与，10414名来自美国22个地点的儿童参与了为期2年的随访。我们探讨了产前大麻暴露与认知能力和脑容量发育轨迹之间的关系。在11,530名具有产前大麻暴露有效数据的儿童中，10,833名儿童在产前没有使用大麻，697名儿童在怀孕期间使用大麻。怀孕期间吸食大麻与时间点对视觉知觉加工能力（b = - 0.019, p = 0.009）和颅内容积（b = - 6338.309, p = 0.009）有显著的交互作用。我们发现，怀孕期间接触大麻的影响在任何时候都是不一致的，随着发育的进展，可能会逐渐变得更加明显和放大。
Although cannabis use during pregnancy is increasing widely, the effects of cannabis on developmental trajectories, such as whether its effects during pregnancy remain the same between time points or gradually increase, are unclear. This study aimed to examine whether cannabis use during pregnancy affects the process of change in cognition and brain volume. Data from two-time points measured longitudinally were analyzed. We used data from the Adolescent Brain and Cognitive Development Study. Participants included 11,876 children aged 9–11 years participated at baseline, and 10,414 participated at 2-year follow-up from 22 sites across the United States. We explored the associations between prenatal cannabis exposure and cognitive abilities and brain volumes developmental trajectories. Among 11,530 children with valid data for prenatal cannabis exposure, 10,833 had no prenatal cannabis use, and 697 had cannabis use during their pregnancy. There was a significant interaction between time points and cannabis use during pregnancy on visuo-perceptual processing ability (b = −0.019, p = .009) and intracranial volumes (b = −6338.309, p = .009). We found that the effects of exposure to cannabis during pregnancy are not uniform at all times and may gradually become more apparent and magnified as development progresses.
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影响因子：
4.7
作者：
Casey BJ;Cannonier T;Conley MI;Cohen AO;Barch DM;Heitzeg MM;Soules ME;Teslovich T;Dellarco DV;Garavan H;Orr CA;Wager TD;Banich MT;Speer NK;Sutherland MT;Riedel MC;Dick AS;Bjork JM;Thomas KM;Chaarani B;Mejia MH;Hagler DJ Jr;Daniela Cornejo M;Sicat CS;Harms MP;Dosenbach NUF;Rosenberg M;Earl E;Bartsch H;Watts R;Polimeni JR;Kuperman JM;Fair DA;Dale AM;ABCD Imaging Acquisition Workgroup
通讯作者：
ABCD Imaging Acquisition Workgroup
影响因子：
4.7
作者：
Haller SPW;Mills KL;Hartwright CE;David AS;Cohen Kadosh K
通讯作者：
Cohen Kadosh K
影响因子：
2.9
作者：
FRIED, PA;WATKINSON, B
通讯作者：
WATKINSON, B
影响因子：
2.9
作者：
Fried, PA;Watkinson, B;Gray, R
通讯作者：
Gray, R
影响因子：
2.9
作者：
Fried, PA;Watkinson, B;Gray, R
通讯作者：
Gray, R