Ferulic Acid Ameliorates Atherosclerotic Injury by Modulating Gut Microbiota and Lipid Metabolism.
Ferulic Acid Ameliorates Atherosclerotic Injury by Modulating Gut Microbiota and Lipid Metabolism.
复制标题
DOI：
10.3389/fphar.2021.621339
复制
发表时间：
2021
影响因子：
5.6
通讯作者：
Zhou F
中科院分区：
文献类型：
--
作者：
Gu Y;Zhang Y;Li M;Huang Z;Jiang J;Chen Y;Chen J;Jia Y;Zhang L;Zhou F
动脉粥样硬化是全球死亡的主要原因。最近的研究强调了肠道菌群和脂质代谢在动脉粥样硬化发展中的重要性。在此，使用ApoE敲除（ApoE-scin-c57 BL/6背景）小鼠模型检查涉及阿魏酸（FA）在动脉粥样硬化中的作用和分子机制。将18只雄性ApoE−/−小鼠喂饲高脂饲料12周后随机分为模型组、FA（40 mg/kg/d）组和辛伐他汀（5 mg/kg/d）组。结果表明，FA能显著减轻小鼠动脉粥样硬化，调节血脂水平。FA还减轻了HFD诱导的肝损伤和肝细胞脂肪变性。FA通过上调AMPKα磷酸化水平和下调SREBP 1和ACC 1表达改善脂质代谢。此外，FA诱导肠道微生物群和粪便代谢物的显著结构变化，并特异性地降低了Fimicutes，丹毒丝菌科和Ileibacterium的相对丰度，这与动脉粥样硬化小鼠的血脂水平呈正相关。结论：FA可显著改善动脉粥样硬化损伤，其机制可能是通过AMPKα/SREBP 1/ACC 1途径调节肠道菌群和脂质代谢。
Atherosclerosis is a leading cause of death worldwide. Recent studies have emphasized the significance of gut microbiota and lipid metabolism in the development of atherosclerosis. Herein, the effects and molecular mechanisms involving ferulic acid (FA) was examined in atherosclerosis using the ApoE-knockout (ApoE-∕-, c57BL/6 background) mouse model. Eighteen male ApoE−/− mice were fed a high-fat diet (HFD) for 12 weeks and then randomly divided into three groups: the model group, the FA (40 mg/kg/day) group and simvastatin (5 mg/kg/day) group. As results, FA could significantly alleviate atherosclerosis and regulate lipid levels in mice. Liver injury and hepatocyte steatosis induced by HFD were also mitigated by FA. FA improved lipid metabolism involving up-regulation of AMPKα phosphorylation and down-regulation of SREBP1 and ACC1 expression. Furthermore, FA induced marked structural changes in the gut microbiota and fecal metabolites and specifically reduced the relative abundance of Fimicutes, Erysipelotrichaceae and Ileibacterium, which were positively correlated with serum lipid levels in atherosclerosis mice. In conclusion, we demonstrate that FA could significantly ameliorate atherosclerotic injury, which may be partly by modulating gut microbiota and lipid metabolism via the AMPKα/SREBP1/ACC1 pathway.
登录
查看更多内容
影响因子：
4.3
作者：
Kwon, E. Y.;Do, G. M.;Choi, M. S.
通讯作者：
Choi, M. S.
影响因子：
30.3
作者：
Araujo, Joao R.;Tazi, Asmaa;Sansonetti, Philippe J.
通讯作者：
Sansonetti, Philippe J.
影响因子：
2.5
作者：
Coqueiro, Audrey Yule;Raizel, Raquel;Tirapegui, Julio
通讯作者：
Tirapegui, Julio
影响因子：
4.3
作者：
Dey, Tiyasa;Ghosh, Auroma;Bandyopadhyay, Debasish
通讯作者：
Bandyopadhyay, Debasish
影响因子：
5.9
作者：
Deroover, Lise;Verspreet, Joran;Verbeke, Kristin
通讯作者：
Verbeke, Kristin