Anticorrelated resting-state functional connectivity in awake rat brain.
Anticorrelated resting-state functional connectivity in awake rat brain.
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DOI：
10.1016/j.neuroimage.2011.08.009
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发表时间：
2012-01-16
期刊：
影响因子：
5.7
通讯作者：
Zhang, Nanyin
中科院分区：
文献类型：
--
作者：
Liang, Zhifeng;King, Jean;Zhang, Nanyin
通过功能磁共振成像测量的静息态功能连接（RSFC）在理解神经回路和脑部疾病方面发挥了重要作用。绝大多数 RSFC 研究都集中在正 RSFC，而我们对其概念对应物——负 RSFC（即反相关）的理解仍然难以捉摸。迄今为止，在没有常用的全局信号校正预处理步骤的情况下，尚未观察到反相关的 RSFC。然而，此步骤可能会引起人为反相关，从而难以确定在人类中观察到的反相关是否是处理人为。在本报告中，我们在清醒大鼠的下边缘皮层 (IL) 和杏仁核之间的明确表征的额边缘回路中证明了强大的反相关 RSFC。这种反相关性具有解剖学特异性、高度可重复性并且独立于预处理方法。有趣的是，即使有全局信号回归，这种反相关关系在麻醉大鼠中也不存在，这进一步支持了其功能意义。建立独立于数据预处理方法的负 RSFC 将显着增强 RSFC 在更好地理解神经回路和大脑网络方面的适用性。此外，结合啮齿类动物 IL-杏仁核回路的神经生物学数据，本研究的发现将有助于进一步研究反相关的神经生物学基础。
Resting-state functional connectivity (RSFC) measured by functional magnetic resonance imaging has played an essential role in understanding neural circuitry and brain diseases. The vast majority of RSFC studies have been focused on positive RSFC, whereas our understanding about its conceptual counterpart—negative RSFC (i.e. anticorrelation)—remains elusive. To date, anticorrelated RSFC has yet been observed without the commonly used preprocessing step of global signal correction. However, this step can induce artifactual anticorrelation, making it difficult to determine whether the observed anticorrelation in humans is a processing artifact. In this report we demonstrated robust anticorrelated RSFC in a well characterized frontolimbic circuit between the infralimbic cortex (IL) and amygdala in the awake rat. This anticorrelation was anatomically specific, highly reproducible and independent of preprocessing methods. Interestingly, this anticorrelated relationship was absent in anesthetized rats even with global signal regression, further supporting its functional significance. Establishing negative RSFC independent of data preprocessing methods will significantly enhance the applicability of RSFC in better understanding neural circuitries and brain networks. In addition, combining the neurobiological data of the IL-amygdala circuit in rodents, the finding of the present study will enable further investigation of the neurobiological basis underlying anticorrelation.
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DOI：
10.1073/pnas.0504136102
发表时间：
2005-07-05
影响因子：
11.1
作者：
Fox, MD;Snyder, AZ;Raichle, ME
通讯作者：
Raichle, ME
DOI：
10.1016/j.cub.2009.04.028
发表时间：
2009-06-23
期刊：
Current biology : CB
影响因子：
--
作者：
Albert NB;Robertson EM;Miall RC
通讯作者：
Miall RC
影响因子：
4.8
作者：
Hampson, M;Peterson, BS;Gore, JC
通讯作者：
Gore, JC
影响因子：
1.7
作者：
Peltier, SJ;Kerssens, C;Hu, XP
通讯作者：
Hu, XP
影响因子：
10.6
作者：
Greicius, Michael D.;Flores, Benjamin H.;Schatzberg, Alan F.
通讯作者：
Schatzberg, Alan F.