Altered dipsogenic responses and expression of angiotensin receptors in the offspring exposed to prenatal high sucrose.
Altered dipsogenic responses and expression of angiotensin receptors in the offspring exposed to prenatal high sucrose.
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暴露于产前高蔗糖的后代中血管紧张素受体表达的改变
DOI：
10.1016/j.peptides.2010.10.012
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发表时间：
2011-01
期刊：
影响因子：
3
通讯作者：
Xu Z
中科院分区：
文献类型：
--
作者：
Wu L;Mao C;Liu Y;Shi A;Xu F;Zhang L;Xu Z
本研究测定了出生前暴露于高蔗糖的成年后代大鼠的水和盐摄入量以及大脑和肾脏中AT1和AT2受体的表达。在怀孕期间暴露后，成年后代在基线水平上的水摄入量和盐摄入量没有改变。然而，在24小时缺水后，水和盐的消耗量与对照组相比显著增加。血浆钠和渗透压水平在对照组和暴露组的后代之间保持不变，而红细胞压积在产前缺氧后立即暴露于高蔗糖的后代中更高。对照组与暴露组肾脏AT1受体蛋白密度基本一致，而产前高蔗糖暴露子代肾脏AT2受体蛋白密度显著升高，与肾小球基底膜增厚有关。在前脑中，有产前高糖史的后代的AT1和AT2受体水平均显著升高。此外，在暴露于产前高蔗糖的后代中，缺水导致中央发病区域（包括室旁核和视上核）的c-fos表达增加。结果提示，产前高蔗糖摄入可能影响脱水时发病行为调控通路的发育，这与肾脏和大脑中AT1或/和AT2受体的表达改变有关。
The present study determined water and salt intake as well as expression of AT1 and AT2 receptors in the brain and kidney in the adult offspring rats prenatally exposed to high sucrose. Following the exposure during pregnancy, water intake and salt intake at baseline levels were not changed in the adult offspring. However, after 24 hour water deprivation, consumption of water and salt was significantly increased compared to that of the control. Plasma sodium and osmolality levels remained the same between the offspring in the control and the exposed groups, while hematocrit was higher in the offspring exposed to prenatal high sucrose immediately following water deprivation. Density of renal AT1 receptor protein was the same between the control and the exposed group, while AT2 receptor protein in the kidney was significantly increased in the offspring exposed to prenatal high sucrose in association of thicker basal membrane of glomerular. In the forebrain, both AT1 and AT2 receptor levels were significantly increased in the offspring with history of prenatal high sucrose. In addition, water deprivation induced more c-fos expression in the central dipsogenic areas, including the paraventricular and supraoptic nuclei in the offspring exposed to prenatal high sucrose. The results suggested that prenatal high intake of sucrose may affect development of pathways in regulation of dipsogenic behavior in face of dehydration, which was associated with altered expression of AT1 or/and AT2 receptors in the kidney and brain.
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影响因子：
6.7
作者：
Mao C;Shi L;Xu F;Zhang L;Xu Z
通讯作者：
Xu Z
影响因子：
2.5
作者：
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通讯作者：
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影响因子：
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作者：
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通讯作者：
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影响因子：
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作者：
MAHON, JM;ALLEN, M;FITZSIMONS, JT
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影响因子：
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作者：
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通讯作者：
Xu, Zhice