C-Reactive Protein: Pathophysiology, Diagnosis, False Test Results and a Novel Diagnostic Algorithm for Clinicians.
C-Reactive Protein: Pathophysiology, Diagnosis, False Test Results and a Novel Diagnostic Algorithm for Clinicians.
复制标题
DOI：
10.3390/diseases11040132
复制
发表时间：
2023-09-28
期刊：
影响因子：
--
通讯作者：
中科院分区：
文献类型：
--
作者：
目前的文献提供了大量关于C反应蛋白(CRP)及其在炎症中的潜在作用的证据。然而，大多数证据都很稀少，而且存在争议。这本关键的最先进的专著提供了关于蛋白质潜在生化性质的所有关键数据，以及关于其五聚体和单体形式的潜在病理生物学的进一步证据，包括其配体的信息以及针对蛋白质的自身抗体的可能功能。此外，目前的证据表明其作为各种疾病的生物标记物的潜在效用，包括所有心血管、呼吸系统、肝胆、胃肠、胰腺、肾脏、妇科、男科、牙科、口腔、耳鼻咽喉科、眼科、皮肤科、肌肉骨骼、神经、精神、脾、甲状腺疾病，以及感染、自身免疫假想疾病和肿瘤，包括与该蛋白浓度升高有关的其他可能因素。此外，还讨论了有关C反应蛋白的分子诊断数据，并强调了错误检测结果的可能原因。此外，这篇综述还评估了目前关于CRP和全身炎症的所有证据，并强调了未来的目标。最后，说明了一种新的诊断算法，用于仔细评估CRP水平，以精确诊断医疗状况。
The current literature provides a body of evidence on C-Reactive Protein (CRP) and its potential role in inflammation. However, most pieces of evidence are sparse and controversial. This critical state-of-the-art monography provides all the crucial data on the potential biochemical properties of the protein, along with further evidence on its potential pathobiology, both for its pentameric and monomeric forms, including information for its ligands as well as the possible function of autoantibodies against the protein. Furthermore, the current evidence on its potential utility as a biomarker of various diseases is presented, of all cardiovascular, respiratory, hepatobiliary, gastrointestinal, pancreatic, renal, gynecological, andrological, dental, oral, otorhinolaryngological, ophthalmological, dermatological, musculoskeletal, neurological, mental, splenic, thyroid conditions, as well as infections, autoimmune-supposed conditions and neoplasms, including other possible factors that have been linked with elevated concentrations of that protein. Moreover, data on molecular diagnostics on CRP are discussed, and possible etiologies of false test results are highlighted. Additionally, this review evaluates all current pieces of evidence on CRP and systemic inflammation, and highlights future goals. Finally, a novel diagnostic algorithm to carefully assess the CRP level for a precise diagnosis of a medical condition is illustrated.
登录
查看更多内容
影响因子：
2.7
作者：
Liang Y;Xu K;Liu W;Liu X;Yuan P;Xu P;Li H
通讯作者：
Li H
影响因子：
3.4
作者：
Sundström B;Ljung L;Wållberg-Jonsson S
通讯作者：
Wållberg-Jonsson S
婴儿和儿童严重百日咳的临床特征分析：一项回顾性研究。
影响因子：
2.4
作者：
Wang C;Zhang H;Zhang Y;Xu L;Miao M;Yang H;Liu Y;He S;Pang L
通讯作者：
Pang L
影响因子：
2.2
作者：
Bolhuis, Thomas E.;Marsman, Diane;van den Hoogen, Frank H. J.;den Broeder, Alfons A.;den Broeder, Nathan;van der Maas, Aatke
通讯作者：
van der Maas, Aatke
DOI：
10.1177/20552173221139768
发表时间：
2022-10
影响因子：
2.8
作者：
Grut, Viktor;Bistrom, Martin;Salzer, Jonatan;Stridh, Pernilla;Lindam, Anna;Alonso-Magdalena, Lucia;Andersen, Oluf;Jons, Daniel;Gunnarsson, Martin;Vrethem, Magnus;Hultdin, Johan;Sundstrom, Peter
通讯作者：
Sundstrom, Peter