Systemic inflammation and risk of multiple sclerosis - A presymptomatic case-control study.

Systemic inflammation and risk of multiple sclerosis - A presymptomatic case-control study.
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DOI:
10.1177/20552173221139768
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发表时间:
2022-10
影响因子:
2.8
通讯作者:
Sundstrom, Peter
Sundstrom, Peter
中科院分区:
其他
文献类型:
--
作者:
Grut, Viktor;Bistrom, Martin;Salzer, Jonatan;Stridh, Pernilla;Lindam, Anna;Alonso-Magdalena, Lucia;Andersen, Oluf;Jons, Daniel;Gunnarsson, Martin;Vrethem, Magnus;Hultdin, Johan;Sundstrom, Peter

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C反应蛋白(CRP)是全身炎症的标志物。有人建议年轻人提高 CRP 水平可以降低多发性硬化症 (MS) 的风险。评估 CRP 作为 MS 的危险因素。使用高灵敏度免疫测定法测量生物库样本中的 CRP 水平,这些样本来自后来发展为 MS 的 837 名个体和 984 名匹配对照者。通过 z 评分 CRP 值的条件逻辑回归分析发生 MS 的风险。 CRP 水平与 MS 风险无关。我们发现 CRP 水平与 MS 发展风险之间没有关联。
C-reactive protein (CRP) is a marker of systemic inflammation. Increased levels of CRP in young persons have been suggested to decrease the risk of multiple sclerosis (MS). To assess CRP as a risk factor for MS. Levels of CRP were measured with a high-sensitive immunoassay in biobank samples from 837 individuals who later developed MS and 984 matched controls. The risk of developing MS was analysed by conditional logistic regression on z-scored CRP values. Levels of CRP were not associated with MS risk. We found no association between CRP levels and risk of MS development.
DOI: 10.1177/1352458512472752
发表时间: 2013-07-01
影响因子: 5.8
作者:
Salzer, Jonatan;Hallmans, Goran;Sundstrom, Peter
通讯作者: Sundstrom, Peter
DOI: 10.1177/1352458520905033
发表时间: 2020-02-07
影响因子: 5.8
作者:
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通讯作者: Sundstrom, Peter
DOI: 10.1177/2055217319892291
发表时间: 2019-10-01
影响因子: 2.8
作者:
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通讯作者: Sundstrom, Peter
DOI: 10.1038/s41572-018-0041-4
发表时间: 2018-11-08
影响因子: 81.5
作者:
Filippi, Massimo;Bar-Or, Amit;Rocca, Maria A.
通讯作者: Rocca, Maria A.