Progesterone from maternal circulation binds to progestin receptors in fetal brain.
Progesterone from maternal circulation binds to progestin receptors in fetal brain.
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孕妇循环的孕酮与胎儿脑中的孕激素受体结合。
DOI：
10.1002/dneu.22462
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发表时间：
2017-06
影响因子：
3
通讯作者：
Quadros-Mennella P
中科院分区：
文献类型：
--
作者：
Wagner CK;Quadros-Mennella P
类固醇激素激活核受体，作为转录因子，可以调节神经发育的关键方面。围产期大鼠前脑、中脑和后脑的许多区域表达孕激素受体（PR），提示孕激素可能在大脑发育中起重要作用。采用免疫组织化学方法，使用两种对配体结合的PR具有差异识别的抗体来检测胎儿在怀孕期间是否暴露于母体黄体酮，以及母体循环中的黄体酮是否可以与胎儿大脑内的PR结合。研究结果表明，在妊娠结束时，母体和胎儿血清黄体酮水平呈正相关，表明母体和胎儿（例如母体卵巢）的黄体酮有一个共同的来源。另外的研究结果表明，母亲服用外源性孕酮不仅在2小时内增加胎儿血清孕酮水平，而且似乎增加了胎儿大脑中配体结合的PR。这些发现表明，母体来源的黄体酮可能在神经发育中起着以前被忽视的作用。此外，对孕妇持续预防性使用合成黄体酮预防早产也有影响。
Steroid hormones activate nuclear receptors which, as transcription factors, can regulate critical aspects of neural development. Many regions of the rat forebrain, midbrain and hindbrain express progestin receptors (PR) during perinatal life, suggesting that progesterone may play an important role in the development of the brain. An immunohistochemical approach using two antibodies with differential recognition of ligand-bound PR was used to examine whether fetuses are exposed to maternal progesterone during pregnancy and whether progesterone from maternal circulation can bind to PR within the fetal brain. Findings demonstrate that maternal and fetal serum progesterone levels are positively correlated at the end of gestation, suggesting a common source of progesterone in mothers and fetuses (e.g., the maternal ovary). Additional findings suggest that administration of exogenous progesterone to mothers not only increases fetal serum progesterone levels within 2 h, but appears to increase ligand-bound PR in fetal brain. These findings suggest that progesterone of maternal origin may play a previously overlooked role in neural development. In addition, there are implications for the ongoing prophylactic use of synthetic progestins in pregnant women for the prevention of premature birth.
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影响因子：
4.3
作者：
Lenz KM;Nugent BM;McCarthy MM
通讯作者：
McCarthy MM
影响因子：
2.5
作者：
Quadros, Princy S.;Pfau, Jennifer L.;Wagner, Christine K.
通讯作者：
Wagner, Christine K.
影响因子：
3
作者：
Quadros, Princy S.;Schlueter, Lisa J.;Wagner, Christine K.
通讯作者：
Wagner, Christine K.
影响因子：
4.8
作者：
QUATTROPANI, SL;WEISZ, J
通讯作者：
WEISZ, J
DOI：
10.1007/7854_2014_286
发表时间：
2014-01-01
期刊：
NEUROBIOLOGY OF CHILDHOOD
影响因子：
--
作者：
de Vries, Geert J.;Fields, Christopher T.;Paul, Matthew J.
通讯作者：
Paul, Matthew J.