A conformal, bio-interfaced class of silicon electronics for mapping cardiac electrophysiology.
A conformal, bio-interfaced class of silicon electronics for mapping cardiac electrophysiology.
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DOI：
10.1126/scitranslmed.3000738
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发表时间：
2010-03-24
影响因子：
17.1
通讯作者：
Litt B
中科院分区：
文献类型：
--
作者：
Viventi J;Kim DH;Moss JD;Kim YS;Blanco JA;Annetta N;Hicks A;Xiao J;Huang Y;Callans DJ;Rogers JA;Litt B
当前植入式医疗设备的复杂性和分辨率受到将每个传感器单独连接到数据采集系统的需要的限制。这些设备采样和调制组织的能力进一步受到电子器件和电极-组织界面的刚性、平面性质的限制。在这里，我们报告了一类机械柔性硅电子器件的发展，用于在人体软组织的动态三维表面上以亲密的、共形的集成模式测量信号。我们在由2016硅纳米膜晶体管组成的传感器系统中说明了这种技术，该传感器系统被配置为直接从体内跳动心脏的弯曲潮湿表面记录电活动。该设备通过288个放大和多路复用通道同时进行亚毫米和亚毫秒分辨率采样。我们使用这些系统在猪动物模型的心外膜表面上以高分辨率真实的时间映射自发和起搏心室去极化的传播。这种临床规模的演示代表了这种技术在微创医疗设备中的许多可能用途的一个例子。[与活组织紧密集成的共形电子器件和传感器使新一代植入式设备能够解决人类健康中的重要问题。
The sophistication and resolution of current implantable medical devices are limited by the need connect each sensor separately to data acquisition systems. The ability of these devices to sample and modulate tissues is further limited by the rigid, planar nature of the electronics and the electrode-tissue interface. Here, we report the development of a class of mechanically flexible silicon electronics for measuring signals in an intimate, conformal integrated mode on the dynamic, three dimensional surfaces of soft tissues in the human body. We illustrate this technology in sensor systems composed of 2016 silicon nanomembrane transistors configured to record electrical activity directly from the curved, wet surface of a beating heart in vivo. The devices sample with simultaneous sub-millimeter and sub-millisecond resolution through 288 amplified and multiplexed channels. We use these systems to map the spread of spontaneous and paced ventricular depolarization in real time, at high resolution, on the epicardial surface in a porcine animal model. This clinical-scale demonstration represents one example of many possible uses of this technology in minimally invasive medical devices. [Conformal electronics and sensors intimately integrated with living tissues enable a new generation of implantable devices capable of addressing important problems in human health.]
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影响因子：
56.9
作者：
Khang, DY;Jiang, HQ;Rogers, JA
通讯作者：
Rogers, JA
DOI：
10.1111/j.1151-2916.1985.tb16160.x
发表时间：
1985-01-01
影响因子：
3.9
作者：
MICHALSKE, TA;FULLER, ER
通讯作者：
FULLER, ER
影响因子：
37.8
作者：
SCHERLAG, BJ;LAU, SH;DAMATO, AN
通讯作者：
DAMATO, AN
影响因子：
1.1
作者：
MEDHURST, PL;FOSTER, DJ
通讯作者：
FOSTER, DJ
DOI：
10.1073/pnas.0807476105
发表时间：
2008-12-02
影响因子：
11.1
作者：
Kim, Dae-Hyeong;Song, Jizhou;Rogers, John A.
通讯作者：
Rogers, John A.