Convergent and divergent gray matter volume abnormalities in unaffected first-degree relatives and ultra-high risk individuals of schizophrenia.
Convergent and divergent gray matter volume abnormalities in unaffected first-degree relatives and ultra-high risk individuals of schizophrenia.
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DOI：
10.1038/s41537-022-00261-9
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发表时间：
2022-06-04
期刊：
影响因子：
--
通讯作者：
Wang, Lu-Bin
中科院分区：
文献类型：
--
作者：
Lin, Bei;Li, Xian-Bin;Ruan, Sen;Wu, Yu-Xin;Zhang, Chao-Yue;Wang, Chuan-Yue;Wang, Lu-Bin
精神分裂症的高危人群主要可以根据推定的内表型确定为遗传高危或根据临床表现的症状确定为超高风险（UHR）。以前的研究一直表明，遗传高危和UHR个体的大脑结构异常。在这项研究中，我们的目的是解开UHR和未受影响的一级亲属之间的遗传高危个体的灰质改变的收敛和发散模式。我们使用结构MRI扫描和基于体素的形态计量学方法，研究了23名符合前驱综合征结构化访谈（SIPS）标准的UHR受试者、18名未受影响的一级亲属（UFDR）、26名首发精神分裂症患者（FES）和54名健康对照者（CN）的灰质体积（GMV）差异。我们发现，一些脑区表现出单调递减的趋势，从CN到UFDR到UHR到FES。与正常对照组相比，UHR组患者颞下回、梭状回、枕中回、颞叶、边缘区的GMV明显降低。此外，UHR转化亚组在右侧颞下/梭状回的GMV显著低于UHR非转化亚组。另一方面，UFDR受试者仅在颞下回和梭状回显示出显著的GMV降低。枕叶GMV与UHR患者SIPS复合阳性症状呈负相关，小脑GMV与FES患者症状严重程度呈正相关。我们的研究结果表明，GMV赤字和区域功能障碍是明显的精神病发作前，更突出的UHR比UFDR个人。
High-risk populations of schizophrenia can be mainly identified as genetic high-risk based on putative endophenotypes or ultra-high-risk (UHR) based on clinically manifested symptoms. Previous studies have consistently shown brain structural abnormalities in both genetic high-risk and UHR individuals. In this study, we aimed to disentangle the convergent and divergent pattern of gray matter alterations between UHR and unaffected first-degree relatives from genetic high-risk individuals. We used structural MRI scans and voxel-based morphometry method to examine gray matter volume (GMV) differences among 23 UHR subjects meeting the Structured Interview for Prodromal Syndromes (SIPS) criteria, 18 unaffected first-degree relatives (UFDR), 26 first-episode schizophrenia patients (FES) and 54 healthy controls (CN). We found that a number of brain regions exhibited a monotonically decreasing trend of GMV from CN to UFDR to UHR to FES. Compared with CN, the UHR subjects showed significant decreases of GMV similar to the patients in the inferior temporal gyrus, fusiform gyrus, middle occipital gyrus, insula, and limbic regions. Moreover, the UHR transformed subgroup had significantly lower GMV than UHR non-transformed subgroup in the right inferior temporal/fusiform gyrus. On the other hand, the UFDR subjects only showed significant GMV decreases in the inferior temporal gyrus and fusiform. Moreover, we found GMV in the occipital lobe was negatively correlated with the UHR subjects’ composite positive symptom of SIPS, and GMV in the cerebellum was positively correlated with FES subjects’ symptom severity. Our results suggest that GMV deficits and regional dysfunction are evident prior to the onset of psychosis and are more prominent in the UHR than the UFDR individuals.
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影响因子：
4.7
作者：
Takayanagi Y;Kulason S;Sasabayashi D;Takahashi T;Katagiri N;Sakuma A;Ohmuro N;Katsura M;Nishiyama S;Nakamura M;Kido M;Furuichi A;Noguchi K;Matsumoto K;Mizuno M;Ratnanather JT;Suzuki M
通讯作者：
Suzuki M
影响因子：
4.5
作者：
Keshavan, MS;Dick, E;DeBellis, M
通讯作者：
DeBellis, M
影响因子：
6
作者：
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通讯作者：
Conway BR
影响因子：
19.9
作者：
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通讯作者：
Mishkin M
影响因子：
10.6
作者：
Borgwardt, Stefan J.;Picchioni, Marco M.;McGuire, Philip K.
通讯作者：
McGuire, Philip K.