Bisphenol and phthalate concentrations and its determinants among pregnant women in a population-based cohort in the Netherlands, 2004-5.
Bisphenol and phthalate concentrations and its determinants among pregnant women in a population-based cohort in the Netherlands, 2004-5.
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DOI：
10.1016/j.envres.2017.11.051
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发表时间：
2018-03
影响因子：
8.3
通讯作者：
Trasande L
中科院分区：
文献类型：
--
作者：
Philips EM;Jaddoe VWV;Asimakopoulos AG;Kannan K;Steegers EAP;Santos S;Trasande L
怀孕期间接触双酚和邻苯二甲酸酯可能会对妇女及其后代的健康产生不利影响。描述妊娠早期尿液中双酚和邻苯二甲酸酯的浓度，包括双酚和邻苯二甲酸酯替代物，并确定营养、社会人口统计学和生活方式相关的决定因素。在一项基于人群的前瞻性队列研究中，我们测量了1396名母亲的孕早期双酚、邻苯二甲酸酯和肌酐尿浓度（样本收集于2004 - 2005年，中位胎龄12.9周[四分位距（IQR）12.1 - 14.4]）。我们研究了潜在的决定因素与对数转换双酚和邻苯二甲酸酯浓度的关联。结果是反向转化的。营养分析仅在642名荷兰参与者的亚组中进行，因为食物频率问卷针对荷兰食物模式。双酚A、双酚S和双酚F的检出率分别为79.2%、67.8%和40.2%。邻苯二甲酸单正丁酯、邻苯二甲酸单（2-乙基-5-羟己基）酯和邻苯二甲酸单苄酯在> 90%的人群中检出。营养摄入量与双酚和邻苯二甲酸酯浓度校正后，应用多重测试。肥胖与较高的高分子量邻苯二甲酸酯浓度和缺乏叶酸补充剂与较高的邻苯二甲酸二正辛酯浓度相关（各自的平均差异为46.73 nmol/l [95% CI 14.56 - 93.72]和1.03 nmol/l [0.31 - 2.06]）。早在2004 - 2005年，荷兰孕妇接触双酚S和F的情况就很普遍。虽然饮食和其他关键因素与双酚和邻苯二甲酸酯浓度的关联有限，但不良生活方式因素，包括肥胖和缺乏叶酸补充剂的使用，似乎与孕妇邻苯二甲酸酯浓度较高有关。主要限制是每位参与者只能获得一份尿样。然而，由于据报告邻苯二甲酸酯随时间推移相当稳定，因此预计邻苯二甲酸酯浓度决定因素的结果具有稳健性。
Exposure to bisphenols and phthalates in pregnancy may lead to adverse health effects in women themselves and their offspring. To describe first trimester bisphenol and phthalate urine concentrations, including bisphenol and phthalate replacements, and determine nutritional, socio-demographic and lifestyle related determinants. In a population-based prospective cohort of 1396 mothers, we measured first trimester bisphenol, phthalate and creatinine urine concentrations (samples collected in 2004–2005, median gestational age 12.9 weeks [inter-quartile range (IQR) 12.1–14.4]). We examined associations of potential determinants with log-transformed bisphenol and phthalate concentrations. Outcomes were back-transformed. Nutritional analyses were performed in a subgroup of 642 Dutch participants only, as the Food Frequency Questionnaire was aimed at Dutch food patterns. Bisphenol A, bisphenol S, and bisphenol F were detected in 79.2%, 67.8% and 40.2% of the population, respectively. Mono-n-butylphthalate, mono-(2-ethyl-5-hydroxyhexyl)phthalate and monobenzylphthalate were detected in > 90% of the population. Nutritional intake was not associated with bisphenol and phthalate concentrations after correction for multiple testing was applied. Obesity was associated with higher high-molecular-weight phthalate concentrations and the lack of folic acid supplement use with higher di-n-octylphthalate concentrations (respective mean differences were 46.73 nmol/l [95% CI 14.56–93.72] and 1.03 nmol/l [0.31–2.06]). Bisphenol S and F exposure was highly prevalent in pregnant women in the Netherlands as early as 2004–5. Although associations of dietary and other key factors with bisphenol and phthalate concentrations were limited, adverse lifestyle factors including obesity and the lack of folic acid supplement use seem to be associated with higher phthalate concentrations in pregnant women. The major limitation was the availability of only one urine sample per participant. However, since phthalates are reported to be quite stable over time, results concerning determinants of phthalate concentrations are expected to be robust.
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影响因子：
11.8
作者：
Cantonwine, David E.;Cordero, Jose F.;Rivera-Gonzalez, Luis O.;Del Toro, Liza V. Anzalota;Ferguson, Kelly K.;Mukherjee, Bhramar;Calafat, Antonia M.;Crespo, Noe;Jimenez-Velez, Braulio;Padilla, Ingrid Y.;Alshawabkeh, Akram N.;Meeker, John D.
通讯作者：
Meeker, John D.
影响因子：
3.6
作者：
Braun JM;Sathyanarayana S;Hauser R
通讯作者：
Hauser R
影响因子：
8.3
作者：
Asimakopoulos, Alexandros G.;Xue, Jingchuan;Kannan, Kurunthachalam
通讯作者：
Kannan, Kurunthachalam
影响因子：
--
作者：
Koch, HM;Preuss, R;Angerer, J
通讯作者：
Angerer, J
影响因子：
11.8
作者：
Arbuckle, Tye E.;Davis, Karelyn;Fraser, William D.
通讯作者：
Fraser, William D.