Applicability and implementation of the collagen-induced arthritis mouse model, including protocols (Review).
Applicability and implementation of the collagen-induced arthritis mouse model, including protocols (Review).
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DOI：
10.3892/etm.2021.10371
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发表时间：
2021-09
影响因子：
2.7
通讯作者：
Gou X
中科院分区：
文献类型：
--
作者：
Luan J;Hu Z;Cheng J;Zhang R;Yang P;Guo H;Nan G;Guo N;Gou X
类风湿关节炎(RA)动物模型是研究RA体内发病机制和确定抗RA药物疗效的基础。在过去的几十年里，许多关节炎的啮齿动物模型被评估为潜在的模型，建模方法也比较成熟。在这些模型中，胶原诱导性关节炎(CIA)小鼠模型是首选和应用最广泛的模型，因为它可以快速、廉价地产生并且在发病机制上与人类类风湿关节炎(RA)比较相似。到目前为止，已经有许多经典的研究和综述讨论了相关的发病机制和建模方法。在此基础上，结合最新的便捷有效的CIA模型构建方法，本综述旨在向初学者介绍该模型，并阐明其使用的重要细节。简要总结了CIA模型的起源和发病机制、建立该模型的方法、关节炎诱导的成功率和用于评估关节炎严重程度的方法。有了这些信息，预计最近进入该领域或不熟悉这些信息的研究人员将能够快速上手，避免不必要的错误，并获得可靠的结果。
Animal models of rheumatoid arthritis (RA) are essential for studying the pathogenesis of RA in vivo and determining the efficacy of anti-RA drugs. During the past decades, numerous rodent models of arthritis have been evaluated as potential models and the modeling methods are relatively well-developed. Among these models, the collagen-induced arthritis (CIA) mouse model is the first choice and the most widely used because it may be generated rapidly and inexpensively and is relatively similar in pathogenesis to human RA. To date, there have been numerous classic studies and reviews discussing related pathogeneses and modeling methods. Based on this knowledge, combined with the latest convenient and effective methods for CIA model construction, the present review aims to introduce the model to beginners and clarify important details regarding its use. Information on the origin and pathogenesis of the CIA model, the protocol for establishing it, the rate of successful arthritis induction and the methods used to evaluate the severity of arthritis are briefly summarized. With this information, it is expected that researchers who have recently entered the field or are not familiar with this information will be able to start quickly, avoid unnecessary errors and obtain reliable results.
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影响因子：
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作者：
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通讯作者：
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影响因子：
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作者：
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作者：
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影响因子：
7.3
作者：
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通讯作者：
Hamilton JA
DOI：
10.1002/jcsm.12280
发表时间：
2018-06
期刊：
Journal of cachexia, sarcopenia and muscle
影响因子：
--
作者：
Alabarse PVG;Lora PS;Silva JMS;Santo RCE;Freitas EC;de Oliveira MS;Almeida AS;Immig M;Teixeira VON;Filippin LI;Xavier RM
通讯作者：
Xavier RM