Anticipatory human subthalamic area beta-band power responses to dissociable tastes correlate with weight gain.
Anticipatory human subthalamic area beta-band power responses to dissociable tastes correlate with weight gain.
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DOI：
10.1016/j.nbd.2021.105348
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发表时间：
2021-07
影响因子：
6.1
通讯作者：
Halpern, Casey H.
中科院分区：
文献类型：
--
作者：
Kakusa, Bina;Huang, Yuhao;Barbosa, Daniel A. N.;Feng, Austin;Gattas, Sandra;Shivacharan, Rajat;Lee, Eric B.;Kuijper, Fiene M.;Saluja, Sabir;Parker, Jonathon J.;Miller, Kai J.;Keller, Corey;Bohon, Cara;Halpern, Casey H.
关键词：
诱人的甜味和脂肪口味在现代饮食中很普遍，这导致了暴饮暴食和肥胖。在动物模型中，丘脑底区在调节食欲和完全性摄食行为中发挥作用，但它在人类摄食中的作用尚不清楚。当参与者(n=5)参与一项旨在激发味觉预期和接受反应的任务时，我们使用了术中丘脑下野电位记录。观察到下丘脑β频段(15-30赫兹)对甜味和中性口味的功率反应都降低了。对味觉中性暗示的预期反应开始于从基线开始的β波段功率立即下降，随后是早期的β波段反弹高于基线。相反，对甜食的预期反应的特点是β波段能量的显著和持续的下降。这些活动模式定位于丘脑底核和黑质。此外，对这种贝塔频段功率信号进行训练的神经网络准确地预测了(AuC≥74%)对应于任何一种口味的单次试验。最后，在开始脑深部刺激治疗后，中性口味的β波段反弹的幅度与体重指数的增加有关。我们提供了丘脑下部区域的歧视性味道编码的初步证据，该编码与调节食欲和消耗行为的控制机制有关。
The availability of enticing sweet, fatty tastes is prevalent in the modern diet and contribute to overeating and obesity. In animal models, the subthalamic area plays a role in mediating appetitive and consummatory feeding behaviors, however, its role in human feeding is unknown. We used intraoperative, subthalamic field potential recordings while participants (n = 5) engaged in a task designed to provoke responses of taste anticipation and receipt. Decreased subthalamic beta-band (15–30 Hz) power responses were observed for both sweet-fat and neutral tastes. Anticipatory responses to taste-neutral cues started with an immediate decrease in beta-band power from baseline followed by an early beta-band rebound above baseline. On the contrary, anticipatory responses to sweet-fat were characterized by a greater and sustained decrease in beta-band power. These activity patterns were topographically specific to the subthalamic nucleus and substantia nigra. Further, a neural network trained on this beta-band power signal accurately predicted (AUC ≥ 74%) single trials corresponding to either taste. Finally, the magnitude of the beta-band rebound for a neutral taste was associated with increased body mass index after starting deep brain stimulation therapy. We provide preliminary evidence of discriminatory taste encoding within the subthalamic area associated with control mechanisms that mediate appetitive and consummatory behaviors.
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影响因子：
25
作者：
Baunez, C;Dias, C;Amalric, M
通讯作者：
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